General Surgery Department, Henan Provincial Children's Hospital, Affiliated Hospital of Zhengzhou University, China.
Comput Math Methods Med. 2022 Jul 21;2022:5802548. doi: 10.1155/2022/5802548. eCollection 2022.
This study further explored the wind direction correlation analysis between serum levels of TGF-1 and VEGF and liver function assessment in children with biliary atresia.
A total of 62 children with biliary atresia (BA) who received surgical treatment in our hospital from October 2020 to October 2021 were selected as the research objects (BA group), and 50 normal healthy children who received routine physical examination in our hospital during the same period were selected as blank control group. Outcome measures included postoperative total bilirubin levels and conjugality of enrolled patients. Bilirubin level, unbound bilirubin level, serum transforming growth factor-beta-1 (TGF-1), vascular endothelial growth factor (VEGF), liver function indicators albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and other observation indicators were included. All data in this study were collected and analyzed by SPSS 23.0 software, and -test was performed.
The serum levels of TGF-1, VEGF, ALT, AST, GGT, and liver hardness were significantly higher in children with jaundice than those without jaundice, and the serum ALB level was significantly lower than that in children without jaundice ( < 0.05). The levels of TGF-1 and VEGF in BA group were positively correlated with the levels of ALT, AST, GGT, and liver hardness ( < 0.05) but negatively correlated with the level of ALB ( < 0.05).
The levels of serum TGF-1 and VEGF in children with biliary atresia have a certain risk correlation with liver function damage, which will become a research focus on the mechanism of liver fibrosis in the diagnosis and treatment of biliary atresia in children.
本研究进一步探讨了血清转化生长因子-β1（TGF-β1）和血管内皮生长因子（VEGF）水平与肝功能评估在胆道闭锁患儿中的风向相关性分析。
选取 2020 年 10 月至 2021 年 10 月在我院接受手术治疗的 62 例胆道闭锁患儿（BA 组）为研究对象，选取同期在我院接受常规体检的 50 例正常健康儿童为空白对照组。观察指标包括术后总胆红素水平和患者的结合性。纳入患者的胆红素水平、未结合胆红素水平、血清转化生长因子-β-1（TGF-β1）、血管内皮生长因子（VEGF）、肝功能指标白蛋白（ALB）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）等。本研究所有数据均采用 SPSS 23.0 软件进行收集和分析，并进行 t 检验。
黄疸患儿血清 TGF-β1、VEGF、ALT、AST、GGT 及肝硬度均明显高于无黄疸患儿，血清 ALB 水平明显低于无黄疸患儿（<0.05）。BA 组患儿 TGF-1 和 VEGF 水平与 ALT、AST、GGT 及肝硬度呈正相关（<0.05），与 ALB 水平呈负相关（<0.05）。
胆道闭锁患儿血清 TGF-β1 和 VEGF 水平与肝功能损伤有一定的风险相关性，将成为儿童胆道闭锁诊断和治疗中肝纤维化机制的研究热点。
