State Key Laboratory of NBC Protection for Civilian, Beijing, P. R. China.
Chem Commun (Camb). 2022 Aug 18;58(67):9393-9396. doi: 10.1039/d2cc02811e.
An efficient and enantioselective phosphonation protocol for construction of chiral α-aminophosphates and α-aminodiarylphosphine oxides has been developed based on chiral phosphoric acid-catalyzed dearomatization of isoquinolines. A series of chiral 1,2-dihydroisoquinolines with dimethoxy phosphoryl or diphenylphosphono substituents at the C1-position were constructed with good to excellent yields and enantioselectivities under mild reaction conditions.
基于手性磷酸催化的异喹啉去芳构化反应，开发了一种高效、对映选择性的膦酰化方法，用于构建手性α-氨基膦酸酯和α-氨基二芳基氧化膦。在温和的反应条件下，一系列在 C1 位带有二甲氧基膦基或二苯膦酰基取代基的手性 1,2-二氢异喹啉以良好至优异的收率和对映选择性得到构建。
