巴西北里奥格兰德州肌萎缩侧索硬化症的地理研究，2005 年至 2018 年。

A geographical study on amyotrophic lateral sclerosis in Rio Grande Do Norte, Brazil, from 2005 to 2018.

机构信息

Department of Mathematics, Federal University of Rio Grande do Norte, Natal, Brazil.

Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, Natal, Brazil.

出版信息

Amyotroph Lateral Scler Frontotemporal Degener. 2023 Feb;24(1-2):117-124. doi: 10.1080/21678421.2022.2102429. Epub 2022 Aug 2.

DOI:10.1080/21678421.2022.2102429

PMID:35916197

Abstract

OBJECTIVE

amyotrophic lateral sclerosis (ALS) is a rare and fatal neurodegenerative disorder with variable incidence and prevalence worldwide. However, clinical-epidemiological studies on ALS are scarce in Brazil. Thus, this study investigated whether ALS incidence had uniform spatial distribution in population-based cluster analysis in Rio Grande do Norte state (Brazil), from 2005 to 2018.

METHODS

new cases of ALS were identified in a database of the ALS multidisciplinary care center of the Onofre Lopes University Hospital in Natal (Rio Grande do Norte, Brazil). Approaches were based on incidence (empirical Bayes estimator and Moran's I analysis) and cluster analyses (Moran scatter plot and spatial correlogram).

RESULTS

a total of 177 patients (59% males) participated in the study; the mean age of ALS onset was 57 years. Mean annual incidence of ALS was 0.3769 per 100,000 inhabitants (95% confidence interval of 0.0889), higher in males than in females (0.4516 per 100,000 0.3044 per 100,000). According to spatial statistics, patients were homogeneously distributed throughout the studied area.

CONCLUSION

a low estimate was observed compared with other populations. Results did not indicate areas of increased risk or significant spatial geographic dependence, suggesting a random ALS incidence in Rio Grande do Norte.

摘要

目的

肌萎缩侧索硬化症（ALS）是一种罕见且致命的神经退行性疾病，其发病率和患病率在全球范围内存在差异。然而，巴西对 ALS 的临床流行病学研究较少。因此，本研究调查了 2005 年至 2018 年巴西北里奥格兰德州（Rio Grande do Norte）基于人群的聚类分析中 ALS 发病率是否具有均匀的空间分布。

方法

在纳塔尔（Rio Grande do Norte，巴西）奥诺弗雷·洛佩斯大学医院 ALS 多学科护理中心的数据库中确定新的 ALS 病例。方法基于发病率（经验贝叶斯估计和 Moran's I 分析）和聚类分析（Moran 散点图和空间相关图）。

结果

共有 177 名患者（59%为男性）参与了研究；ALS 发病的平均年龄为 57 岁。ALS 的年平均发病率为每 10 万人 0.3769 例（95%置信区间为 0.0889），男性高于女性（每 10 万人 0.4516 例每 10 万人 0.3044 例）。根据空间统计学，患者在研究区域内均匀分布。