海洋咔啉葡糖醛酸，一种源自海绵放线菌蓝灰链孢囊菌LHW52806的β-咔啉生物碱新成员。

Marinacarboline glucuronide, a new member of β-carboline alkaloids from sponge-derived actinomycete Actinoalloteichus cyanogriseus LHW52806.

作者信息

Zhang Die, Xu Jing, Qin Qi, An Faliang, Wang Shuping, Li Lei, Lin Houwen

机构信息

College of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, 110000, PR China.

Marine Drugs Research Center, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, PR China.

出版信息

J Antibiot (Tokyo). 2022 Sep;75(9):523-525. doi: 10.1038/s41429-022-00552-4. Epub 2022 Aug 2.

DOI:10.1038/s41429-022-00552-4

PMID:35918477

Abstract

A new member of β-carboline alkaloids, Marinacarboline glucuronide (1), along with nine known compounds (2-10), were isolated from static liquid fermentation extracts of Actinoalloteichus cyanogriseus LHW52806 isolated from the marine sponge Phakellia fusca. Their structures were elucidated by NMR, mass spectrometry and single-crystal X-ray diffraction. All compounds exhibited neither antimicrobial activity nor cytotoxicity. Compounds 1, 8 and 10 showed anti-inflammatory potential of significant decreasing the expressions of IL- 6 in vitro at 20 µM.

摘要

从采自海洋海绵Phakellia fusca的蓝灰放线多孢菌LHW52806的静置液体发酵提取物中，分离得到了一种新型β-咔啉生物碱——海兔咔啉葡糖苷酸（1），以及9种已知化合物（2 - 10）。通过核磁共振、质谱和单晶X射线衍射对它们的结构进行了阐明。所有化合物均未表现出抗菌活性和细胞毒性。化合物1、8和10在20 μM浓度下体外显示出显著降低白细胞介素-6表达的抗炎潜力。