Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
Children's Hospital at Westmead Clinical School, University of Sydney, Sydney, New South Wales, Australia.
Transfusion. 2022 Sep;62(9):1743-1751. doi: 10.1111/trf.17036. Epub 2022 Aug 3.
To examine the extent of hospital-level variation in risk-adjusted rates of postpartum hemorrhage (PPH).
We performed a cross-sectional study examining live births in 257 California hospitals between 2011 and 2015 using linked birth certificate and maternal discharge data. PPH was measured using International Classification of Diseases Codes version 9. Mixed-effects logistic regression models were used to examine the presence and extent of hospital-level variation in PPH before and after adjustment for patient-level risk factors and select hospital characteristics (teaching status and annual delivery volume). Risk-adjusted rates of PPH were estimated for each hospital. The extent of hospital variation was evaluated using the median odds ratio (MOR) and intraclass correlation coefficient (ICC).
Our study cohort comprised 1,904,479 women who had a live birth delivery hospitalization at 247 hospitals. The median, lowest, and highest hospital-specific rates of PPH were 3.48%, 0.54%, and 12.0%, respectively. Similar rates were observed after adjustment for patient and hospital factors (3.44%, 0.60%, and 11.48%). After adjustment, the proportion of the total variation in PPH rates attributable to the hospital was low, with a MOR of 2.02 (95% confidence interval [CI]: 1.89-2.15) and ICC of 14.3% (95% CI: 11.9%-16.3%).
Wide variability exists in the rate of PPH across hospitals in California, not attributable to patient factors, hospital teaching status, and hospital annual delivery volume. Determining whether differences in hospital quality of care explain the unaccounted-for variation in hospital-level PPH rates should be a public health priority.
本研究旨在调查产后出血(PPH)风险调整发生率在医院间的差异程度。
我们开展了一项横断面研究,对 2011 年至 2015 年间加利福尼亚州 257 家医院的活产分娩数据进行了分析,研究数据来源于产妇分娩记录和出生证明。采用国际疾病分类第 9 版编码(ICD-9)来定义 PPH,并使用混合效应逻辑回归模型在调整患者个体特征及部分医院特征(教学医院及年分娩量)后,分析 PPH 发生率的医院间差异及其存在程度。为每个医院计算了风险调整后的 PPH 发生率。使用中位数优势比(MOR)和组内相关系数(ICC)评估医院间变异程度。
本研究纳入了 1904479 名在 247 家医院分娩的产妇,这些产妇的 PPH 发生率中位数、最低值和最高值分别为 3.48%、0.54%和 12.0%。校正了患者个体特征及医院特征后,上述数据分别为 3.44%、0.60%和 11.48%。校正后,PPH 发生率的总变异中仅有很小一部分(14.3%)归因于医院,MOR 为 2.02(95%可信区间:1.89-2.15)。
加利福尼亚州各医院的 PPH 发生率差异较大,这一差异不能用患者个体特征、医院教学性质和年分娩量来解释。明确医院间 PPH 发生率差异是否归因于医疗质量差异,应成为公共卫生领域的关注重点。