Jiang Hong, Signorile Joseph F, Simms Ava-Gaye, Wang Jianhua
Department of Ophthalmology (HJ, JW, A-GS), Bascom Palmer Eye Institute, Department of Neurology (HJ), University of Miami Miller School of Medicine, Miami, Florida; and Department of Kinesiology and Sports Sciences (JFS), University of Miami, Miami, Florida.
J Neuroophthalmol. 2023 Jun 1;43(2):180-184. doi: 10.1097/WNO.0000000000001679. Epub 2022 Aug 2.
To determine the retinal capillary function (RCF, the efficiency of blood flow transferring in the capillary network) and its relation to cognitive function in healthy older people without known cognitive impairment following an 8-week high-speed circuit resistance training program (HSCT).
Eleven subjects in the HSCT group and 7 age-matched nontraining controls (CON) were recruited. The HSCT group trained 3 times per week for 8 weeks, whereas CON performed no formal training. One eye of each subject from both groups was imaged at baseline and 8-week follow-up. Retinal blood flow (RBF) was measured using a retinal function imager, and retinal capillary density (RCD, expressed as fractal dimension Dbox) was measured using optical coherence tomography angiography. RCF was defined as the ratio of RBF to RCD. Cognitive function was assessed during both visits using the NIH Toolbox Fluid Cognition Battery.
RCF was 2.07 ± 0.64 nL⋅s -1 ·Dbox -1 (mean ± SD) at baseline, and significantly increased to 2.59 ± 0.54 nL⋅s -1 ·Dbox -1 after training ( P = 0.0003) in the HSCT group, reflecting an increase of 25%. The changes of RBF were not related to the changes of RCD in the HSCT group (r = -0.18, P = 0.59). There was no significant change of RCF in the CON group ( P = 0.58). In the HSCT group, the Pattern Comparison Processing Speed Test and Fluid Cognition Composite Score were significantly increased after HSCT ( P = 0.01). Furthermore, the changes in Flanker Inhibitory Control and Attention Test (FLNK) were positively correlated to increases in RCF (r = 0.77, P = 0.005).
This is the first prospective study to demonstrate that the increased RCF after HSCT was related to improved cognition in cognitively normal older adults.
在一项为期8周的高速循环阻力训练计划（HSCT）之后，确定健康的无已知认知障碍的老年人的视网膜毛细血管功能（RCF，即毛细血管网络中血流转移的效率）及其与认知功能的关系。
招募了HSCT组的11名受试者和7名年龄匹配的非训练对照组（CON）。HSCT组每周训练3次，共8周，而CON组未进行正式训练。两组中每位受试者的一只眼睛在基线和8周随访时进行成像。使用视网膜功能成像仪测量视网膜血流量（RBF），并使用光学相干断层扫描血管造影测量视网膜毛细血管密度（RCD，以分形维数Dbox表示）。RCF定义为RBF与RCD的比值。在两次访视期间使用美国国立卫生研究院工具箱流体认知电池评估认知功能。
HSCT组基线时RCF为2.07±0.64 nL·s-1·Dbox-1（平均值±标准差），训练后显著增加至2.59±0.54 nL·s-1·Dbox-1（P = 0.0003），反映增加了25%。HSCT组中RBF的变化与RCD的变化无关（r = -0.18，P = 0.59）。CON组中RCF无显著变化（P = 0.58）。在HSCT组中，模式比较处理速度测试和流体认知综合评分在HSCT后显著增加（P = 0.01）。此外，侧翼抑制控制和注意力测试（FLNK）的变化与RCF的增加呈正相关（r = 0.77，P = 0.005）。
这是第一项前瞻性研究，证明HSCT后RCF的增加与认知正常的老年人认知功能改善有关。
