Cesk Slov Oftalmol. 2022 Summer;78(4):160-173. doi: 10.31348/2022/19.
To describe the aetiology and microbial susceptibility profile of endophthalmitis cases treated at an ophthalmological referral centre in Colombia.
A retrospective descriptive study was carried out with all endophthalmitis cases referred to the Fundación Oftalmológica de Santander FOSCAL (Floridablanca, Colombia) from 1 January 2012 to 31 December 2015.
121 eyes of 121 patients were evaluated. 77.7% of them were male and the mean age was 42.9 years. Five of them (4.1%) corresponded to endogenous endophthalmitis, and 116 (95.9%) to exogenous endophthalmitis. Of the latter, 66.9% were associated with trauma (almost one-half of them associated with intraocular foreign body), and 29.5% with intraocular surgery. The most common isolated microorganisms in the exogenous endophthalmitis group corresponded to methicillin-resistant and methicillin-sensitive strains of Staphylococcus epidermidis and Staphylococcus aureus, which were mostly susceptible to imipenem, vancomycin and moxifloxacin and resistant to ceftazidime.
Endophthalmitis is a potentially sight-threatening condition, especially in cases of inadequate treatment. Therefore, antimicrobial therapy should be guided by vitreous humour culture to assure that the causative microorganism is susceptible to the selected agent. The results of our study lead us to propose vancomycin, moxifloxacin or imipenem as first-line antimicrobial options.
描述在哥伦比亚一家眼科转诊中心治疗的眼内炎病例的病因和微生物药敏谱。
对 2012 年 1 月 1 日至 2015 年 12 月 31 日期间转诊至 Santander 眼科基金会（哥伦比亚 Floridablanca）的所有眼内炎病例进行回顾性描述性研究。
共评估了 121 例 121 只眼的患者。其中 77.7%为男性，平均年龄为 42.9 岁。其中 5 例（4.1%）为内源性眼内炎，116 例（95.9%）为外源性眼内炎。后者中，66.9%与创伤有关（其中近一半与眼内异物有关），29.5%与眼内手术有关。在外源性眼内炎组中，最常见的分离微生物为耐甲氧西林和甲氧西林敏感的表皮葡萄球菌和金黄色葡萄球菌，它们对亚胺培南、万古霉素和莫西沙星敏感，对头孢他啶耐药。
眼内炎是一种潜在的威胁视力的疾病，特别是在治疗不充分的情况下。因此，抗微生物治疗应根据玻璃体培养结果进行指导，以确保所选药物对致病微生物敏感。我们的研究结果表明，万古霉素、莫西沙星或亚胺培南可作为一线抗微生物选择。
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