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80 岁以上老年人重大外科手术后的结局:一项全国性队列研究。

Outcomes After Major Surgical Procedures in Octogenarians: A Nationwide Cohort Study.

机构信息

Scientific Bureau, Dutch Institute for Clinical Auditing, 2333 AA, Leiden, The Netherlands.

Department of Hepatobiliary Surgery and Liver Transplantation, Universitair Medisch Centrum Groningen, Groningen, The Netherlands.

出版信息

World J Surg. 2022 Oct;46(10):2399-2408. doi: 10.1007/s00268-022-06642-6. Epub 2022 Aug 4.

Abstract

INTRODUCTION

Aging of the worldwide population has been observed, and postoperative outcomes could be worse in elderly patients. This nationwide study assessed trends in number of surgical resections in octogenarians regarding various major surgical procedures and associated postoperative outcomes.

METHODS

All patients who underwent surgery between 2014 and 2018 were included from Dutch nationwide quality registries regarding esophageal, stomach, pancreas, colorectal liver metastases, colorectal cancer, lung cancer and abdominal aortic aneurysms (AAA). For each quality registry, the number of patients who were 80 years or older (octogenarians) was calculated per year. Postoperative outcomes were length of stay (LOS), 30 day major morbidity and 30 day mortality between octogenarians and younger patients.

RESULTS

No increase in absolute number and proportion of octogenarians that underwent surgery was observed. Median LOS was higher in octogenarians who underwent surgery for colorectal cancer, colorectal liver metastases, lung cancer, pancreatic disease and esophageal cancer. 30 day major morbidity was higher in octogenarians who underwent surgery for colon cancer, esophageal cancer and elective AAA-repair. 30 day mortality was higher in octogenarians who underwent surgery for colorectal cancer, lung cancer, stomach cancer, pancreatic disease, esophageal cancer and elective AAA-repair. Median LOS decreased between 2014 and 2018 in octogenarians who underwent surgery for stomach cancer and colorectal cancer. 30 day major morbidity decreased between 2014 and 2018 in octogenarians who underwent surgery for colon cancer. No trends were observed in octogenarians regarding 30 day mortality between 2014 and 2018.

CONCLUSION

No increase over time in absolute number and proportion of octogenarians that underwent major surgery was observed in the Netherlands. Postoperative outcomes were worse in octogenarians.

摘要

简介

全球人口老龄化现象已经显现,老年患者的术后结果可能更差。这项全国性研究评估了 80 岁以上患者接受各种主要手术的手术数量趋势以及相关的术后结果。

方法

从荷兰全国质量登记处纳入了 2014 年至 2018 年间接受手术的所有患者,包括食管、胃、胰腺、结直肠肝转移、结直肠癌、肺癌和腹主动脉瘤(AAA)。对于每个质量登记处,每年计算 80 岁或以上(80 岁以上)患者的数量。术后结果包括住院时间(LOS)、30 天主要发病率和 30 天死亡率,比较 80 岁以上患者与年轻患者之间的差异。

结果

未观察到接受手术的 80 岁以上患者绝对数量和比例的增加。接受结直肠癌、结直肠肝转移、肺癌、胰腺疾病和食管癌手术的 80 岁以上患者的中位 LOS 较高。接受结肠癌、食管癌和择期 AAA 修复手术的 80 岁以上患者的 30 天主要发病率较高。接受结直肠癌、肺癌、胃癌、胰腺疾病、食管癌和择期 AAA 修复手术的 80 岁以上患者的 30 天死亡率较高。接受胃癌和结直肠癌手术的 80 岁以上患者的中位 LOS 在 2014 年至 2018 年间有所下降。接受结肠癌手术的 80 岁以上患者的 30 天主要发病率在 2014 年至 2018 年间有所下降。在 2014 年至 2018 年间,80 岁以上患者的 30 天死亡率没有趋势。

结论

荷兰没有观察到接受重大手术的 80 岁以上患者的绝对数量和比例随时间增加。80 岁以上患者的术后结果更差。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/158d/9436861/835519b1a1a6/268_2022_6642_Fig1_HTML.jpg

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