Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung, Taiwan.
School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Linkou, Taiwan.
Pediatr Pulmonol. 2022 Nov;57(11):2724-2734. doi: 10.1002/ppul.26089. Epub 2022 Aug 17.
Air pollution is strongly associated with asthma, but has not been determined to induce new-onset asthma development in children with atopic dermatitis (AD).
To assess whether prenatal/postnatal exposure to air pollutants triggers new-onset asthma development in children with AD.
Retrospective cohort study.
PATIENT-SUBJECT SELECTION: Data of patients <age 18 years diagnosed with eczema or AD between 2009 and 2019 were extracted from the multicenter Kaohsiung Medical University Hospital Research Database. Patients diagnosed with new-onset asthma were in the asthma group and patients without asthma history were in the non-asthma group.
The monthly average concentration of air pollutants for 1, 3, and 5 years before the index date, and 3, 6, and 9 months prenatally were analyzed and further stratified by age, immunoglobulin (Ig) E, and the percentage of eosinophil and eosinophil cationic protein (ECP).
Postnatal exposure to airborne particulate matter (PM , PM ), sulfur dioxide (SO ), ozone (O ), carbon monoxide (CO), nitric oxide (NO), nitric dioxide (NO ), and NO , and prenatal exposure to PM , PM , SO , NO, and NO were significantly higher in the asthma group than in the non-asthma group. Patients having IgE above 100 IU/ml and ECP less than 24 ng/ml were significantly influenced by postnatal exposure to PM and PM , especially CO, to develop asthma, and those having an eosinophil count >3% were significantly influenced by prenatal exposure to PM , especially SO , NO, and NO .
Prenatal and postnatal exposure to air pollution have an association with asthma development in AD patients.
空气污染与哮喘密切相关，但尚未确定其是否会导致特应性皮炎（AD）患儿新发性哮喘的发生。
评估产前/产后暴露于空气污染物是否会引发 AD 患儿新发性哮喘的发生。
回顾性队列研究。
患者/受试者选择：从多中心高雄医学大学附属医院研究数据库中提取了 2009 年至 2019 年间诊断为湿疹或 AD 的<18 岁患者的数据。新诊断为哮喘的患者归入哮喘组，无哮喘病史的患者归入非哮喘组。
分析了指数日期前 1、3 和 5 年的空气污染物月平均浓度，以及 3、6 和 9 个月的产前浓度，并根据年龄、免疫球蛋白（Ig）E 以及嗜酸性粒细胞和嗜酸性粒细胞阳离子蛋白（ECP）的百分比进行了进一步分层。
与非哮喘组相比，哮喘组患儿的产后空气颗粒物（PM10、PM2.5）、二氧化硫（SO2）、臭氧（O3）、一氧化碳（CO）、一氧化氮（NO）、二氧化氮（NO2）和二氧化氮（NO2）的暴露量明显更高。IgE 水平>100 IU/ml 和 ECP<24ng/ml 的患者明显受到 PM10 和 PM2.5 的产后暴露的影响，特别是 CO，易发展为哮喘；而嗜酸性粒细胞计数>3%的患者明显受到 PM10、SO2、NO 和 NO2 的产前暴露的影响。
产前和产后暴露于空气污染与 AD 患者哮喘的发生有关。
