尼日利亚开始抗逆转录病毒治疗的 HIV 阳性儿童和青少年的结局（2007-2016 年）。
Outcomes of HIV Positive Children and Adolescents Initiated on Antiretroviral Treatment in Nigeria (2007-2016).
机构信息
12265University of Maryland, Baltimore; Abuja, Nigeria.
12265University of Maryland, Baltimore, MD, USA.
出版信息
J Int Assoc Provid AIDS Care. 2022 Jan-Dec;21:23259582221117009. doi: 10.1177/23259582221117009.
This manuscript aimed to examine treatment outcomes of HIV-positive children and adolescents. We retrospectively analyzed data of a sample of patients aged 0-19 years who initiated ART (October 2007-September 2016) in participating sites in 30 states and the Federal Capital Territory in Nigeria. Among 4006 patients alive at the end of the follow up period, 138 (3.4%) were LTFU. Adolescents had a significantly higher risk of being LTFU than children aged 3-5 years (HR 2.47 [95% CI 1.40-4.34]). Patients with advanced disease had a significantly higher risk of being LTFU (Stage IV HR, 3.66 [95% CI: 2.00-6.68]). On average, optimal ART refill adherence was met by 67.3% of patients. Our findings suggest that focusing on preventing and managing advanced disease and interventions supporting adolescents when transferring to adult care is warranted.
本研究旨在探讨 HIV 阳性儿童和青少年的治疗结局。我们对来自尼日利亚 30 个州和联邦首都区参与研究的 4006 名患者的生存数据进行了回顾性分析，这些患者于 2007 年 10 月至 2016 年 9 月期间开始接受抗逆转录病毒治疗（ART）。在随访期末仍存活的 4006 名患者中，有 138 名（3.4%）为治疗失败。与 3-5 岁的儿童相比，青少年治疗失败的风险显著更高（HR 2.47 [95% CI 1.40-4.34]）。晚期疾病患者的治疗失败风险显著更高（IV 期 HR 3.66 [95% CI：2.00-6.68]）。平均而言，67.3%的患者达到了最佳的 ART 药物续用。我们的研究结果表明，有必要关注预防和管理晚期疾病，并为即将转至成人护理的青少年提供支持。
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