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尼日利亚开始抗逆转录病毒治疗的 HIV 阳性儿童和青少年的结局（2007-2016 年）。

Outcomes of HIV Positive Children and Adolescents Initiated on Antiretroviral Treatment in Nigeria (2007-2016).

机构信息

12265University of Maryland, Baltimore; Abuja, Nigeria.

12265University of Maryland, Baltimore, MD, USA.

出版信息

J Int Assoc Provid AIDS Care. 2022 Jan-Dec;21:23259582221117009. doi: 10.1177/23259582221117009.

DOI:10.1177/23259582221117009
PMID:35929105
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9358598/
Abstract

This manuscript aimed to examine treatment outcomes of HIV-positive children and adolescents. We retrospectively analyzed data of a sample of patients aged 0-19 years who initiated ART (October 2007-September 2016) in participating sites in 30 states and the Federal Capital Territory in Nigeria. Among 4006 patients alive at the end of the follow up period, 138 (3.4%) were LTFU. Adolescents had a significantly higher risk of being LTFU than children aged 3-5 years (HR 2.47 [95% CI 1.40-4.34]). Patients with advanced disease had a significantly higher risk of being LTFU (Stage IV HR, 3.66 [95% CI: 2.00-6.68]). On average, optimal ART refill adherence was met by 67.3% of patients. Our findings suggest that focusing on preventing and managing advanced disease and interventions supporting adolescents when transferring to adult care is warranted.

摘要

本研究旨在探讨 HIV 阳性儿童和青少年的治疗结局。我们对来自尼日利亚 30 个州和联邦首都区参与研究的 4006 名患者的生存数据进行了回顾性分析，这些患者于 2007 年 10 月至 2016 年 9 月期间开始接受抗逆转录病毒治疗（ART）。在随访期末仍存活的 4006 名患者中，有 138 名（3.4%）为治疗失败。与 3-5 岁的儿童相比，青少年治疗失败的风险显著更高（HR 2.47 [95% CI 1.40-4.34]）。晚期疾病患者的治疗失败风险显著更高（IV 期 HR 3.66 [95% CI：2.00-6.68]）。平均而言，67.3%的患者达到了最佳的 ART 药物续用。我们的研究结果表明，有必要关注预防和管理晚期疾病，并为即将转至成人护理的青少年提供支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5de4/9358598/084af9e00b8f/10.1177_23259582221117009-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5de4/9358598/084af9e00b8f/10.1177_23259582221117009-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5de4/9358598/084af9e00b8f/10.1177_23259582221117009-fig1.jpg

相似文献

[1]
Outcomes of HIV Positive Children and Adolescents Initiated on Antiretroviral Treatment in Nigeria (2007-2016).

J Int Assoc Provid AIDS Care. 2022

[2]
High rates of loss to follow-up during the first year of pre-antiretroviral therapy for HIV patients at sites providing pre-ART care in Nigeria, 2004-2012.

PLoS One. 2017-9-1

[3]
Patterns of Adherence and Loss to Follow-Up in Pediatric Patients on ART in Nigeria.

Curr HIV Res. 2015

[4]
Outcomes of Nigeria's HIV/AIDS Treatment Program for Patients Initiated on Antiretroviral Treatment between 2004-2012.

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[5]
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PLoS One. 2020-9-15

[6]
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[7]
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[8]
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[9]
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AIDS Res Ther. 2022-2-22

[10]
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本文引用的文献

[1]
Longitudinal evaluation of adherence, retention, and transition patterns of adolescents living with HIV in Nigeria.

PLoS One. 2020-7-31

[2]
Burden of Clostridium (Clostridioides) difficile infection during inpatient stays in the USA between 2012 and 2016.

J Hosp Infect. 2019-1-25

[3]
CD4+ cell count recovery following initiation of HIV antiretroviral therapy in older childhood and adolescence.

AIDS. 2018-9-10

[4]
Incidence and predictors of loss to follow up among HIV-infected adults at Pawi General Hospital, northwest Ethiopia: competing risk regression model.

BMC Res Notes. 2018-5-10

[5]
Immune activation despite preserved CD4 T cells in perinatally HIV-infected children and adolescents.

PLoS One. 2017-12-29

[6]
Loss to follow-up among children and adolescents growing up with HIV infection: age really matters.

J Int AIDS Soc. 2017-7-17

[7]
Transitioning HIV-infected adolescents to adult care at 14 clinics across the United States: using adolescent and adult providers' insights to create multi-level solutions to address transition barriers.

AIDS Care. 2017-10

[8]
Retention of HIV-Infected Children in the First 12 Months of Anti-Retroviral Therapy and Predictors of Attrition in Resource Limited Settings: A Systematic Review.

PLoS One. 2016-6-9

[9]
How are children with HIV faring in Nigeria?--a 7 year retrospective study of children enrolled in HIV care.

BMC Pediatr. 2015-7-22

[10]
Preliminary investigation of adherence to antiretroviral therapy among children in Aminu Kano Teaching Hospital, Nigeria.

Afr J AIDS Res. 2006-9

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