Wieczorek J, Peczyńska-Czoch W, Mordarski M, Kaczmarek L, Becalski A, Nantka-Namirski P
Arch Immunol Ther Exp (Warsz). 1986;34(3):323-6.
Preliminary screening of the antitumor properties of selected azacarbazoles revealed that of all the compounds tested only 2,7-diazacarbazole (compound IX) and 3,6-diazacarbazole (compound XI) caused the inhibition of Sarcoma 180 growth up to 70%. beta- and gamma-Carbolines and their derivatives in presented testing system were inactive. None of the tested compounds displayed marked activity against murine leukemias and was active in the cytotoxicity test of KB cells.
对选定氮杂咔唑的抗肿瘤特性进行的初步筛选表明，在所有测试的化合物中，只有2,7-二氮杂咔唑（化合物IX）和3,6-二氮杂咔唑（化合物XI）能使肉瘤180的生长抑制率高达70%。在本测试系统中，β-和γ-咔啉及其衍生物无活性。所测试的化合物均未对鼠白血病显示出显著活性，且在KB细胞的细胞毒性试验中也无活性。
