肝豆状核变性中矢状位胼胝体宏观结构异常的形态测量图谱
Morphometric mapping of the macrostructural abnormalities of midsagittal corpus callosum in Wilson's disease.
作者信息
Stezin Albert, Reddam Venkateswara Reddy, Hegde Shantala, Yadav Ravi, Saini Jitender, Pal Pramod Kumar
机构信息
Department of Clinical Neuroscience and Department of Neurology, Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Department of Neuropsychology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
出版信息
Ann Mov Disord. 2021 May 31;4(2):60-65. doi: 10.4103/AOMD.AOMD_41_20.
BACKGROUND AND PURPOSE
The corpus callosum (CC) consists of topographically arranged white matter (WM) fibers. Previous studies have indicated the CC to be discretely involved in WD. In this study, we strived to characterize the macrostructural properties of the CC using midsagittal cross-sectional area and thickness profile measurements.
MATERIALS AND METHODS
This study was performed using archived magnetic resonance imaging (MRI) scans of 14 patients with WD and 14 age- and gender-matched healthy controls. Using an automated software pipeline for morphometric profiling, the midsagittal CC was segmented into five sub-regions (CC) according to the Hofer-Frahm scheme. The mean thickness and area of different CC segments and their clinical and cognitive correlates were identified.
RESULTS
The mean area was significantly different only in CC segment (94.2 ± 25.5 vs. 118.6 ± 19.7 mm, corrected < 0.05). The mean thickness was significantly different in CC (5.06 ± 1.15 vs. 6.93 ± 0.89 mm, corrected < 0.05), CC (3.73 ± 0.96 vs. 4.87 ± 1.01 mm, corrected < 0.05), and CC segments (3.42 ± 0.84 vs. 3.94 ± 0.72 mm, corrected < 0.05). The age at onset of neurological symptoms and MMSE score was significantly correlated with the morphometric changes of CC and CC segments.
CONCLUSION
Morphological changes of the CC are discrete in WD. Morphometric loss of CC was associated with an earlier onset of neurological symptoms and cognitive dysfunction in WD.
背景与目的
胼胝体（CC）由按拓扑结构排列的白质（WM）纤维组成。先前的研究表明CC与威尔逊病（WD）存在特定关联。在本研究中，我们力图通过正中矢状面截面积和厚度轮廓测量来描述CC的宏观结构特性。
材料与方法
本研究使用了14例WD患者以及14例年龄和性别匹配的健康对照者的存档磁共振成像（MRI）扫描数据。使用自动化软件流程进行形态测量分析，根据霍弗-弗拉姆方案将正中矢状面的CC分为五个子区域（CC）。确定了不同CC节段的平均厚度和面积及其临床和认知相关性。
结果
仅CC节段的平均面积存在显著差异（94.2±25.5 vs. 118.6±19.7 mm，校正后<0.05）。CC的平均厚度存在显著差异（5.06±1.15 vs. 6.93±0.89 mm，校正后<0.05），CC的平均厚度也存在显著差异（3.73±0.96 vs. 4.87±1.01 mm，校正后<0.05），CC节段的平均厚度同样存在显著差异（3.42±0.84 vs. 3.94±0.72 mm，校正后<0.05）。神经症状发病年龄和简易精神状态检查表（MMSE）评分与CC和CC节段的形态测量变化显著相关。
结论
WD中CC的形态学变化是特定的。CC的形态测量学改变与WD中神经症状的较早发作和认知功能障碍相关。
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