Davis Jevaughn S, Allais Luca, Abdallah Claude
Department of Anesthesiology, George Washington University School of Medicine and Health Sciences, Washington, USA.
Department of Anesthesiology, Children's National Medical Center, Washington, USA.
Cureus. 2022 Jul 7;14(7):e26646. doi: 10.7759/cureus.26646. eCollection 2022 Jul.
Congenital central hypoventilation syndrome (CCHS) is a rare neurological disease affecting the brain's response to carbon dioxide levels, resulting in dysregulation of respiration. CCHS is characterized by a diminished effort to breathe during sleep despite hypoxia and hypercapnia. Ventilation is adequate during wakeful periods but diminished during sleep. Alterations in ventilation pose a challenge to anesthesiologists in their attempts to wean these patients from ventilatory support. We describe a patient with CCHS and a complicated history of prolonged tracheal intubation, who was treated with intravenous (IV) caffeine and was able to resume adequate spontaneous ventilation and baseline mental status immediately post-procedure.
先天性中枢性低通气综合征（CCHS）是一种罕见的神经系统疾病，影响大脑对二氧化碳水平的反应，导致呼吸调节异常。CCHS的特征是尽管存在低氧血症和高碳酸血症，但睡眠期间呼吸努力减弱。清醒期通气充足，但睡眠期间通气减弱。通气的改变给麻醉医生在试图使这些患者脱离通气支持时带来了挑战。我们描述了一名患有CCHS且有长期气管插管复杂病史的患者，该患者接受了静脉注射咖啡因治疗，术后立即恢复了充足的自主通气和基线精神状态。
