Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin 300000, China.
Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin 300000, China.
Cells. 2022 Jul 28;11(15):2322. doi: 10.3390/cells11152322.
Idiopathic pulmonary fibrosis (IPF) affects an increasing number of people globally, yet treatment options remain limited. At present, conventional treatments depending on drug therapy do not show an ideal effect in reversing the lung damage or extending the lives of IPF patients. In recent years, more and more attention has focused on extracellular vesicles (EVs) which show extraordinary therapeutic effects in inflammation, fibrosis disease, and tissue damage repair in many kinds of disease therapy. More importantly, EVs can be modified or used as a drug or cytokine delivery tool, targeting injury sites to enhance treatment efficiency. In light of this, the treatment strategy of mesenchymal stem cell-extracellular vesicles (MSC-EVs) targeting the pulmonary microenvironment for IPF provides a new idea for the treatment of IPF. In this review, we summarized the inflammation, immune dysregulation, and extracellular matrix microenvironment (ECM) disorders in the IPF microenvironment in order to reveal the treatment strategy of MSC-EVs targeting the pulmonary microenvironment for IPF.
特发性肺纤维化（IPF）在全球范围内影响着越来越多的人群，但治疗选择仍然有限。目前，依赖于药物治疗的常规治疗方法在逆转肺损伤或延长 IPF 患者的生命方面并没有显示出理想的效果。近年来，人们越来越关注细胞外囊泡（EVs），它们在许多疾病的治疗中，如炎症、纤维化疾病和组织损伤修复中具有非凡的治疗效果。更重要的是，EVs 可以被修饰或用作药物或细胞因子的递送工具，靶向损伤部位以提高治疗效率。有鉴于此，针对 IPF 的间充质干细胞-细胞外囊泡（MSC-EVs）靶向肺微环境的治疗策略为 IPF 的治疗提供了一个新的思路。在这篇综述中，我们总结了 IPF 微环境中的炎症、免疫失调和细胞外基质微环境（ECM）紊乱，以揭示针对 IPF 的 MSC-EVs 靶向肺微环境的治疗策略。
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