组蛋白单泛素化在转录调控及其对生命的标记：在组织发育和疾病中的新兴作用。
Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease.
机构信息
The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Science, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
出版信息
Cells. 2022 Aug 4;11(15):2404. doi: 10.3390/cells11152404.
Epigenetic regulation plays an essential role in driving precise transcriptional programs during development and homeostasis. Among epigenetic mechanisms, histone mono-ubiquitination has emerged as an important post-transcriptional modification. Two major histone mono-ubiquitination events are the mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub), placed by Polycomb repressive complex 1 (PRC1), and histone H2B lysine 120 mono-ubiquitination (H2BK120ub), placed by the heteromeric RNF20/RNF40 complex. Both of these events play fundamental roles in shaping the chromatin epigenetic landscape and cellular identity. In this review we summarize the current understandings of molecular concepts behind histone mono-ubiquitination, focusing on their recently identified roles in tissue development and pathologies.
表观遗传调控在驱动发育和稳态过程中的精确转录程序中起着至关重要的作用。在表观遗传机制中，组蛋白单泛素化已成为一种重要的转录后修饰。两种主要的组蛋白单泛素化事件是由多梳抑制复合物 1（PRC1）介导的组蛋白 H2A 赖氨酸 119 单泛素化（H2AK119ub），以及异源二聚体 RNF20/RNF40 复合物介导的组蛋白 H2B 赖氨酸 120 单泛素化（H2BK120ub）。这两个事件都在塑造染色质表观遗传景观和细胞身份方面发挥着基础性作用。在这篇综述中，我们总结了组蛋白单泛素化背后的分子概念的最新认识，重点介绍了它们在组织发育和病理学中的新发现的作用。
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