Shrivastava Jahnavi, Narang Manish, Gomber Sunil
Department of Pediatrics, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India.
Sudan J Paediatr. 2022;22(1):10-18. doi: 10.24911/SJP.106-1621869672.
Heterologous immunity is a well-known concept in immunology wherein prior exposure to an antigen confers cross-protection against an unrelated antigen. With the surge in global COVID-19 cases, there has been significant research into the application of vaccine-induced heterologous immunity associated with measles, mumps and rubella (MMR) vaccine, Bacillus Calmette-Guérin vaccine, oral polio vaccine, and hepatitis A vaccine in curbing the worst outcomes of COVID-19 infection. Despite having specific vaccines against COVID-19, it is worthwhile exploring the application of available vaccines in the prevention of severe disease until the vaccines reach all sections of the population across the globe. In this article, we aim to outline the concept of heterologous immunity and its relevance in context to MMR vaccine and COVID-19.
异源免疫是免疫学中一个广为人知的概念，即先前接触某种抗原可赋予针对不相关抗原的交叉保护作用。随着全球新冠病毒病例激增，人们对与麻疹、腮腺炎和风疹（MMR）疫苗、卡介苗、口服脊髓灰质炎疫苗及甲型肝炎疫苗相关的疫苗诱导异源免疫在遏制新冠病毒感染最坏结果方面的应用进行了大量研究。尽管有针对新冠病毒的特定疫苗，但在疫苗普及到全球所有人群之前，探索现有疫苗在预防重症方面的应用是值得的。在本文中，我们旨在概述异源免疫的概念及其与MMR疫苗和新冠病毒的相关性。
