Cagli Fulya, Dolanbay Mehmet, Gülseren Varol, Disli Gurler Ayse, Aygen Ercan Mustafa
Department of Obstetrics and Gynecology, Erciyes University, Kayseri, Turkey.
Department of Obstetrics and Gynecology, Kayseri City Hospital, Kayseri, Turkey.
J Obstet Gynaecol. 2022 Oct;42(7):3199-3203. doi: 10.1080/01443615.2022.2109141. Epub 2022 Aug 12.
In our retrospective cohort study, we aimed to determine the role of endometrial thickness (ET) in isolated male factor infertile women fertilisation/intracytoplasmic sperm injection (IVF/ICSI) fresh embryo cycles. The patients were classified as having an endometrial thickness of <7 mm (: 80), 7-9.9 mm (: 335), 10-14 mm (: 579) and >14 mm (: 50) according to their ETs on the human chorionic gonadotropin (hCG) day. The overall clinical pregnancy rate was 37.4%, and no significant difference was found between the groups ( = .262). There was no significant difference between live birth rates ( = .094), but the highest pregnancy (46%) and live birth (34%) rates were found in the group with >14 mm ET. The increase in ET in IVF cycles increases pregnancy rates, albeit partially. When it is desired to determine a cut-off value, it can be said that pregnancy rates increase significantly in thicknesses of 14 mm and above.Impact Statement When the literature is examined, many studies conclude that clinical pregnancy rates increase with the increase in endometrial thickness (ET) in IVF cycles, but there are also studies that argue the opposite. There is no study in the literature investigating the effect of ET on clinical pregnancy rates in patients with isolated male factor infertility. In support of the literature, an increase in ET was found to be associated with an increase in clinical pregnancy rates, regardless of male and female factors. Although pregnancy occurs in thin endometriums, abortion rates are undesirably high. Although the risk of abortion is high in thin endometriums, live birth rates are satisfactory. As a result, thin endometrium does not require cycle cancellation.
在我们的回顾性队列研究中,我们旨在确定子宫内膜厚度(ET)在男性因素不育女性进行体外受精/卵胞浆内单精子注射(IVF/ICSI)新鲜胚胎周期中的作用。根据患者在人绒毛膜促性腺激素(hCG)日的子宫内膜厚度,将其分为<7mm组(n = 80)、7 - 9.9mm组(n = 335)、10 - 14mm组(n = 579)和>14mm组(n = 50)。总体临床妊娠率为37.4%,各组之间未发现显著差异(P = 0.262)。活产率之间无显著差异(P = 0.094),但ET>14mm组的妊娠率(46%)和活产率(34%)最高。IVF周期中ET的增加会提高妊娠率,尽管只是部分提高。当希望确定一个临界值时,可以说14mm及以上厚度时妊娠率会显著增加。影响声明 查阅文献时,许多研究得出结论,IVF周期中临床妊娠率随子宫内膜厚度(ET)增加而升高,但也有研究持相反观点。文献中没有研究调查ET对单纯男性因素不育患者临床妊娠率的影响。支持文献观点的是,发现ET增加与临床妊娠率增加相关,无论男女因素如何。虽然薄子宫内膜也会发生妊娠,但流产率高得不理想。虽然薄子宫内膜流产风险高,但活产率令人满意。因此,薄子宫内膜不需要取消周期。