Fibroscan® 和剪切波在慢性肝病患者肝纤维化评估中具有良好的相关性，“在真实生活环境下”。

Fibroscan® and Shear Wave correlated well in hepatic fibrosis evaluation of patients with chronic liver diseases "in real life situation".

机构信息

Department of Hepatology and Gastroenterology, GHPSO, Creil, France.

Department of Hepatology and Gastroenterology, Souro Sanou University Hospital, Bobo Dioulasso, Burkina Faso.

出版信息

Medicine (Baltimore). 2022 Aug 12;101(32):e30025. doi: 10.1097/MD.0000000000030025.

DOI:10.1097/MD.0000000000030025

PMID:35960072

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9371580/

Abstract

BACKGROUND

A new noninvasive medical device based on ultrasound elastography such as the Shear Wave Elastography (SWE) was designed in order to measure the liver hardness. The purpose of this work was to evaluate the correlation of the results of the liver elasticity measurements obtained by Fibroscan® (FS) and SWE for patients with chronic liver diseases.

METHODS

Between January and October 2017, the patients who were followed during this period of time underwent noninvasive assessments of liver fibrosis by SWE in the intercostal spaces during abdominal ultrasound procedures and/or FS. The correlation between FS and SWE was estimated and tested at a 0.05 significance level.

RESULTS

Four hundred and seventy-six patients were included in this study. The main etiologies of chronic liver disease were non alcoholic fatty disease (NAFLD), chronic viral hepatitis B (HBV) and chronic viral hepatitis C (HCV). All patients underwent a SWE and 167 among them underwent a FS procedure. The patients who were followed revealed a median FS measurement of 5.80 kpa (Q25 = 4.90 kPa; Q75 = 8 kPa) and a median SWE measurement of 7.00 kPa (Q25 = 6.10 kPa; Q75 = 8.10 kPa). We could observe a significant correlation between the FS and SWE measurements (0.49; P = .001) in the total cohort. The average absolute difference between the measurements of these 2 methods was of 2.54 kPa (sd = 3.39). There was no significant correlation for patients with NAFLD no matter whether they presented with signs of suspected non alcoholic steatohepatitis (NASH) or not (R = 0.20; P = .108). All patients intending to perform the examination were able to undergo the SWE, allowing 33.3% of the patients who failed the FS to have a noninvasive evaluation of their fibrosis.

CONCLUSION

The SWE technique proved to be as efficient as the FS one for the evaluation of the liver fibrosis in real life situation.

摘要

背景

为了测量肝脏硬度，设计了一种基于超声弹性成像的新型无创医疗设备，即剪切波弹性成像（SWE）。本研究旨在评估慢性肝病患者通过 Fibroscan®（FS）和 SWE 获得的肝脏弹性测量结果之间的相关性。

方法

2017 年 1 月至 10 月期间，在此期间接受随访的患者在腹部超声检查过程中通过肋间 SWE 进行非侵入性肝纤维化评估，和/或 FS。在 0.05 的显著性水平下估计和测试 FS 和 SWE 之间的相关性。

结果

本研究共纳入 476 例患者。慢性肝病的主要病因是非酒精性脂肪性肝病（NAFLD）、慢性乙型肝炎病毒（HBV）和慢性丙型肝炎病毒（HCV）。所有患者均接受了 SWE 检查，其中 167 例患者接受了 FS 检查。随访患者的 FS 测量中位数为 5.80 kPa（Q25 = 4.90 kPa；Q75 = 8 kPa），SWE 测量中位数为 7.00 kPa（Q25 = 6.10 kPa；Q75 = 8.10 kPa）。我们可以观察到总队列中 FS 和 SWE 测量之间存在显著相关性（0.49；P =.001）。这两种方法测量值的平均绝对差值为 2.54 kPa（标准差 = 3.39）。对于无论是否存在非酒精性脂肪性肝炎（NASH）可疑迹象的 NAFLD 患者，两种方法之间均无相关性（R = 0.20；P =.108）。所有打算进行检查的患者均能够进行 SWE，使 33.3%未能进行 FS 的患者能够对其纤维化进行非侵入性评估。