门诊胃肠外抗菌治疗（OPAT）作为儿科特定PROA项目一部分的影响
Impact of an outpatient parenteral antimicrobial treatment (OPAT) as part of a paediatric-specific PROA program.
作者信息
Fernández-Polo Aurora, Ramon-Cortes Sonia, Plaja-Dorca Judith, Bartolomé-Comas Rosa, Vidal-Valdivia Lis, Soler-Palacín Pere
机构信息
Servicio de Farmacia, Hospital Infantil, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Catalonia, Spain.
Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.
出版信息
Enferm Infecc Microbiol Clin (Engl Ed). 2023 Apr;41(4):230-234. doi: 10.1016/j.eimce.2022.08.004. Epub 2022 Aug 10.
INTRODUCTION
Outpatient parenteral antimicrobial treatment (OPAT) is an alternative to in-patient care in carefully selected patients. This study presents a self-administration OPAT program integrated within the pediatric antibiotic stewardship program (ASP) in a pediatric tertiary care center.
MATERIAL AND METHODS
Descriptive, retrospective and unicentric study. Data from all patients under 20 years of age who were prescribed treatment by a pediatric unit during 2019 and 2020 were included. Data regarding number of saved beds and estimating the opportunity cost of the OPAT program for the hospital were analyzed.
RESULTS
Fifty-seven patients received 106 episodes of treatment. Favorable clinical outcome occurred in 74.5% of the episodes. The main cause of premature interruption was unfavorable clinical outcome of the infection (37.1%). A total of 2.62 beds/day were saved, resulting in an economic benefit of 1,069,963 €.
CONCLUSION
A self-administration OPAT program integrated within the pediatric ASP has proven to be safe and effective and provides economic benefits.
引言
对于经过精心挑选的患者，门诊胃肠外抗菌治疗（OPAT）是住院治疗的一种替代方案。本研究介绍了在一家儿科三级护理中心的儿科抗生素管理计划（ASP）中纳入的一项自我管理OPAT计划。
材料与方法
描述性、回顾性单中心研究。纳入了2019年至2020年期间由儿科病房开出处方进行治疗的所有20岁以下患者的数据。分析了节省的病床数量以及估算该OPAT计划对医院的机会成本的数据。
结果
57名患者接受了106次治疗。74.5%的治疗取得了良好的临床结果。提前中断治疗的主要原因是感染的临床结果不佳（37.1%）。总共节省了2.62个床位/天，产生了1,069,963欧元的经济效益。
结论
已证明纳入儿科ASP的自我管理OPAT计划是安全有效的，并具有经济效益。
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