Gene Regulation Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute (NCI), Bethesda, MD 20892-1500, USA.
Gene Regulation Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute (NCI), Bethesda, MD 20892-1500, USA.
Trends Cell Biol. 2023 Mar;33(3):235-246. doi: 10.1016/j.tcb.2022.07.006. Epub 2022 Aug 10.
The MYC protooncogene functions as a universal amplifier of transcription through interaction with numerous factors and complexes that regulate almost every cellular process. However, a comprehensive model that explains MYC's actions and the interplay governing the complicated dynamics of components of the transcription and replication machinery is still lacking. Here, we review the potency of MYC as an oncogenic driver and how it regulates the broad spectrum of complexes (effectors and regulators). We propose a 'hand-over model' for differential partitioning and trafficking of unstructured MYC via a loose interaction network between various gene-regulatory complexes and factors. Additionally, the article discusses how unstructured-MYC energetically favors efficient modulation of the energy landscape of the transcription cycle.
原癌基因 MYC 通过与众多调节几乎所有细胞过程的因子和复合物相互作用，作为转录的通用放大器发挥作用。然而，一个能够解释 MYC 作用以及调控转录和复制机制组件复杂动力学的综合模型仍然缺乏。在这里，我们回顾了 MYC 作为致癌驱动因子的效力，以及它如何调节广泛的复合物（效应物和调节剂）。我们提出了一个“交接模型”，用于通过各种基因调节复合物和因子之间的松散相互作用网络对无结构 MYC 进行差异分区和运输。此外，本文还讨论了无结构-MYC 如何在能量上有利于有效地调节转录循环的能量景观。
