Vargo Patrick R, Tarola Christopher L, Durbak Emily, Doh Chang Yoon, Caputo Francis J, Smolock Christopher J, Roselli Eric E
Aorta Center, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.
Department of Thoracic and Cardiovascular Surgery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.
JTCVS Tech. 2022 Apr 20;14:1-8. doi: 10.1016/j.xjtc.2022.04.011. eCollection 2022 Aug.
Debakey type I and IIIb aortic dissections are complicated by extension along the full length of the aorta. Over the long term, the thoracoabdominal aorta in these patients often continues to degenerate, requiring endovascular or open repair. The purpose of this investigation is to determine the early clinical outcome on aortic remodeling using a composite thoracic stent graft and thoracoabdominal bare metal extension stenting strategy.
From April 2019 to April 2021, 73 patients with Debakey I/IIIb aortic dissection underwent endovascular stent graft repair of the descending thoracic aorta and repair of the thoracoabdominal aorta using bare metal extension stenting. Preoperative and follow-up surveillance computed tomography imaging scans were analyzed.
Fifty-three (73%) patients had a Debakey I aortic dissection, and 50 (69%) patients underwent surgery during the chronic (time to surgery >30 days) dissection phase. Mortality at 30 days was 4% (3 hyperacute patients). Stroke occurred in 3 (4%), paraparesis in 2 (2.7%), and acute renal failure requiring dialysis occurred in 2 (2.7%) patients. On postoperative and follow-up computed tomography, there was a significant increase in false lumen thrombosis ( < .001). This coincided with a significant increase in true lumen fraction suggestive of positive aortic remodeling ( < .001) at the time of latest follow-up.
Altering the course of aortic remodeling, with placement of a dissection stent in the thoracoabdominal aorta simultaneous with descending thoracic aortic repair may promote true lumen re-expansion and false lumen thrombosis during acute and chronic dissection phases.
Debakey I型和IIIb型主动脉夹层会沿主动脉全长扩展,导致病情复杂。从长期来看,这些患者的胸腹主动脉常持续退变,需要进行血管腔内修复或开放手术修复。本研究的目的是确定采用复合胸段支架移植物和胸腹段裸金属延长支架置入策略对主动脉重塑的早期临床疗效。
2019年4月至2021年4月,73例Debakey I/IIIb型主动脉夹层患者接受了胸降主动脉血管腔内支架移植物修复及胸腹主动脉裸金属延长支架置入修复。对术前及随访的计算机断层扫描成像进行分析。
53例(73%)患者为Debakey I型主动脉夹层,50例(69%)患者在慢性(手术时间>30天)夹层期接受手术。30天死亡率为4%(3例超急性期患者)。3例(4%)发生卒中,2例(2.7%)发生截瘫,2例(2.7%)患者发生需要透析的急性肾衰竭。术后及随访计算机断层扫描显示,假腔血栓形成显著增加(<0.001)。这与最新随访时提示主动脉重塑良好的真腔比例显著增加(<0.001)相一致。
在胸降主动脉修复的同时,在胸腹主动脉置入夹层支架以改变主动脉重塑进程,可能会促进急性和慢性夹层期的真腔再扩张和假腔血栓形成。