Leitschuh M, Chobanian A V
Hypertension. 1987 Jun;9(6 Pt 2):III106-9. doi: 10.1161/01.hyp.9.6_pt_2.iii106.
The ability of propranolol to inhibit the development of polyploidy in aortic vascular smooth muscle cells associated with hypertension was studied in deoxycorticosterone (DOC)-salt treated rats. Six-week treatment with DOC-salt resulted in significant increases in systolic blood pressure, heart weight, and aortic weight in treated animals compared to increases in uninephrectomized controls. Additionally, the percentage of tetraploid nuclei in aortic smooth muscle cells increased to 17.0 +/- 0.2% in DOC-salt treated rats versus 7.8 +/- 0.3% in normotensive controls. Administration of propranolol (500 mg/L in drinking water) did not inhibit the development of hypertension for up to 4 weeks or the associated increase in cardiac or aortic weight in DOC-salt-treated rats, but did prevent the increase in polyploidy of aortic smooth muscle cell nuclei (8.9 +/- 0.9% in propranolol-treated rats compared to 7.8 +/- 0.3% in normotensive controls). These results indicate that propranolol inhibits the development of hypertension-induced polyploidy in aortic smooth muscle cells of DOC-salt-treated rats and that factors other than blood pressure may be important in this change.
在脱氧皮质酮（DOC）-盐处理的大鼠中，研究了普萘洛尔抑制与高血压相关的主动脉血管平滑肌细胞多倍体形成的能力。与未切除单侧肾脏的对照组相比，DOC-盐处理6周导致处理组动物的收缩压、心脏重量和主动脉重量显著增加。此外，DOC-盐处理大鼠的主动脉平滑肌细胞中四倍体细胞核的百分比增加到17.0±0.2%，而正常血压对照组为7.8±0.3%。给予普萘洛尔（饮用水中500 mg/L）在长达4周的时间内并未抑制DOC-盐处理大鼠的高血压发展或心脏或主动脉重量的相关增加，但确实阻止了主动脉平滑肌细胞核多倍体的增加（普萘洛尔处理的大鼠中为8.9±0.9%，而正常血压对照组为7.8±0.3%）。这些结果表明，普萘洛尔抑制了DOC-盐处理大鼠主动脉平滑肌细胞中高血压诱导的多倍体形成，并且血压以外的因素在这种变化中可能很重要。
