Ibarra Rodríguez Maria Rosa, Garrido Pérez Jose Ignacio, Rueda Fernando Vázquez, Murcia Pascual Francisco Javier, Wiesner Torres Sandra Rocio, Paredes Esteban Rosa Maria
Department of Pediatric Surgery, Reina Sofia University Hospital, Córdoba, Spain.
Ann Thorac Med. 2022 Jul-Sep;17(3):145-150. doi: 10.4103/atm.atm_14_22. Epub 2022 Jul 9.
The objective of this study is to compare the outcome of treatment with drainage and urokinase (UK) versus thoracoscopy (TS) in pleural empyema secondary to complicated pneumonia.
This was a retrospective study of patients with complicated parapneumonic effusions between 2008 and 2019 treated with UK or TS. Epidemiological and evolutionary data compared days of fever, antibiotic, pre- and postprocedure stay, time to radiological resolution, and complications. The results were expressed as medians and the comparisons were made by the Mann-Whitney U-test.
Of 143 patients with NC, 46 were empyemas (26 men), 25 were treated with TS, and 10 were treated with UK. The remaining 11 received combined treatment, being excluded from the study. There were no significant differences between TS versus UK in age (median 4 vs. 3 years), days of fever before the procedure (4 vs. 2) and after (2 vs. 2), days of antibiotic treatment before the procedure (4 vs. 4), overall hospital stay (15 vs. 13 days), and months until radiological normalization (2 vs. 2). The complications related to the therapy were scarce in both groups and had no impact on evolution. Patients with TS had a longer preprocedural stay (4 vs. 1; < 0.001) and required fewer days of subsequent antibiotic after procedure (8 vs. 11; = 0.03), and a shorter overall antibiotic treatment time (11 vs. 16; = 0.03). They also had a shorter post-TS stay (9 vs. 12 days), although this difference did not become significant ( = 0.09).
In our experience, the results obtained with both procedures are quite similar, although patients undergoing TS had a better evolution (fewer days of antibiotic and a tendency to less hospitalization), despite having been performed in more evolved patients.
本研究的目的是比较胸腔闭式引流联合尿激酶(UK)与胸腔镜(TS)治疗复杂性肺炎继发胸腔积脓的疗效。
这是一项对2008年至2019年间接受UK或TS治疗的复杂性肺炎旁胸腔积液患者的回顾性研究。流行病学和病情演变数据比较了发热天数、抗生素使用情况、术前和术后住院时间、影像学恢复时间及并发症。结果以中位数表示,采用Mann-Whitney U检验进行比较。
143例非复杂性肺炎旁胸腔积液患者中,46例为胸腔积脓(26例男性),25例接受TS治疗,10例接受UK治疗。其余11例接受联合治疗,被排除在研究之外。TS组与UK组在年龄(中位数4岁对3岁)、术前发热天数(4天对2天)、术后发热天数(2天对2天)、术前抗生素治疗天数(4天对4天)、总住院时间(15天对13天)以及影像学恢复正常所需月数(2个月对2个月)方面均无显著差异。两组治疗相关并发症均较少,且对病情演变无影响。TS组患者术前住院时间较长(4天对1天;P<0.001),术后所需后续抗生素使用天数较少(8天对11天;P=0.03),总抗生素治疗时间较短(11天对16天;P=0.03)。TS组术后住院时间也较短(9天对12天),尽管这一差异未达到显著水平(P=0.09)。
根据我们的经验,两种治疗方法的结果相当相似,尽管接受TS治疗的患者病情改善更佳(抗生素使用天数更少且住院时间有缩短趋势),尽管这些患者病情更为严重。