通过应对肥胖流行来缓解乳腺癌差异。
Mitigating Breast Cancer Disparities by Addressing the Obesity Epidemic.
作者信息
Elreda Lauren, Kim Angelina, Malik Manmeet
机构信息
Breast Surgical and Medical Oncology, New York-Presbyterian Queens, Weill Cornell Medicine, 58-04 Main Street, Flushing, New York, NY USA.
出版信息
Curr Breast Cancer Rep. 2022;14(4):168-173. doi: 10.1007/s12609-022-00460-4. Epub 2022 Aug 3.
PURPOSE OF REVIEW
Obese breast cancer patients have poorer outcomes compared to non-obese patients. The intent of this review is to discuss recent studies and analyses regarding the status of the obesity epidemic and its effect on breast cancer incidence and outcomes. Subsequently, we will introduce a program implemented at a New York City hospital to reduce the morbidity and mortality of breast cancer patients with obesity.
RECENT FINDINGS
The prevalence of obesity among adult Americans is 42%, spanning all racial and socioeconomic groups. Importantly, obesity is associated with multiple chronic diseases including cancer. Among breast cancer patients, obesity is linked to higher mortality and poorer clinical outcomes, including but not limited to distant recurrence and secondary malignancies.
SUMMARY
Current treatment of breast cancer patients does not address the link between obesity and poorer prognosis. Here, we present a general strategy for reducing the morbidity and mortality of obese breast cancer patients by addressing the obesity epidemic.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s12609-022-00460-4.
综述目的
与非肥胖患者相比，肥胖乳腺癌患者的预后较差。本综述旨在讨论近期有关肥胖流行状况及其对乳腺癌发病率和预后影响的研究与分析。随后，我们将介绍纽约市一家医院实施的一项旨在降低肥胖乳腺癌患者发病率和死亡率的项目。
最新发现
美国成年人肥胖患病率为42%，涵盖所有种族和社会经济群体。重要的是，肥胖与包括癌症在内的多种慢性疾病相关。在乳腺癌患者中，肥胖与更高的死亡率和更差的临床结局相关，包括但不限于远处复发和继发性恶性肿瘤。
总结
目前对乳腺癌患者的治疗并未解决肥胖与较差预后之间的关联。在此，我们提出一种通过应对肥胖流行来降低肥胖乳腺癌患者发病率和死亡率的总体策略。
补充信息
网络版包含可在10.1007/s12609-022-00460-4获取的补充材料。
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