Koul Roshan, Maiwall Rakhi, Alam Seema, Pamecha Vineynder, Tevethia Harsh Vardhan, Sarin Shiv K
Department of Neurology, Institute of Liver and Biliary Sciences (ILBS), Delhi, India.
Department of Hepatology, Institute of Liver and Biliary Sciences (ILBS), Delhi, India.
J Neurosci Rural Pract. 2022 Aug 13;13(3):476-482. doi: 10.1055/s-0042-1750136. eCollection 2022 Jul.
Seizures are reported in 20 to 30% of cases with chronic liver disease in association with hepatic encephalopathy. Majority of these are focal seizures. Ictal blinking is reported first time in these patients pre- and post-liver transplant. From November 2018 to October 2021, retrospective data was analyzed in patients with end-stage liver disease and hepatic encephalopathy, both pre- and post-liver transplant. Eight patients had ictal blinking, four were pre-transplant and four post-transplant. Five patients (four after liver transplant and one pre-transplant) were seizure free, three died of liver disease and multiorgan dysfunction, and one did not follow-up. Ictal blinking in relation to liver disease and hepatic encephalopathy is reported, often missed and requires short duration antiepileptic medications.
据报道,20%至30%的慢性肝病合并肝性脑病患者会出现癫痫发作。其中大多数为局灶性癫痫发作。肝移植前后的这些患者首次报告有发作期眨眼现象。2018年11月至2021年10月,对终末期肝病和肝性脑病患者肝移植前后的回顾性数据进行了分析。8例患者有发作期眨眼现象,4例为肝移植前,4例为肝移植后。5例患者(4例肝移植后和1例肝移植前)无癫痫发作,3例死于肝病和多器官功能障碍,1例失访。据报道,发作期眨眼与肝病和肝性脑病有关,常被漏诊,需要短期使用抗癫痫药物。