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院前针刺减压与需急诊胸部减压创伤患者死亡率的关联。

Association of Prehospital Needle Decompression With Mortality Among Injured Patients Requiring Emergency Chest Decompression.

机构信息

Division of General/Trauma Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Department of Emergency Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

出版信息

JAMA Surg. 2022 Oct 1;157(10):934-940. doi: 10.1001/jamasurg.2022.3552.

DOI:10.1001/jamasurg.2022.3552
PMID:35976642
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9386601/
Abstract

IMPORTANCE

Prehospital needle decompression (PHND) is a rare but potentially life-saving procedure. Prior studies on chest decompression in trauma patients have been small, limited to single institutions or emergency medical services (EMS) agencies, and lacked appropriate comparator groups, making the effectiveness of this intervention uncertain.

OBJECTIVE

To determine the association of PHND with early mortality in patients requiring emergent chest decompression.

DESIGN, SETTING, AND PARTICIPANTS: This was a retrospective cohort study conducted from January 1, 2000, to March 18, 2020, using the Pennsylvania Trauma Outcomes Study database. Patients older than 15 years who were transported from the scene of injury were included in the analysis. Data were analyzed between April 28, 2021, and September 18, 2021.

EXPOSURES

Patients without PHND but undergoing tube thoracostomy within 15 minutes of arrival at the trauma center were the comparison group that may have benefited from PHND.

MAIN OUTCOMES AND MEASURES

Mixed-effect logistic regression was used to determine the variability in PHND between patient and EMS agency factors, as well as the association between risk-adjusted 24-hour mortality and PHND, accounting for clustering by center and year. Propensity score matching, instrumental variable analysis using EMS agency-level PHND proportion, and several sensitivity analyses were performed to address potential bias.

RESULTS

A total of 8469 patients were included in this study; 1337 patients (11%) had PHND (median [IQR] age, 37 [25-52] years; 1096 male patients [82.0%]), and 7132 patients (84.2%) had emergent tube thoracostomy (median [IQR] age, 32 [23-48] years; 6083 male patients [85.3%]). PHND rates were stable over the study period between 0.2% and 0.5%. Patient factors accounted for 43% of the variation in PHND rates, whereas EMS agency accounted for 57% of the variation. PHND was associated with a 25% decrease in odds of 24-hour mortality (odds ratio [OR], 0.75; 95% CI, 0.61-0.94; P = .01). Similar results were found in patients who survived their ED stay (OR, 0.68; 95% CI, 0.52-0.89; P < .01), excluding severe traumatic brain injury (OR, 0.65; 95% CI, 0.45-0.95; P = .03), and restricted to patients with severe chest injury (OR, 0.72; 95% CI, 0.55-0.93; P = .01). PHND was also associated with lower odds of 24-hour mortality after propensity matching (OR, 0.79; 95% CI, 0.62-0.98; P = .04) when restricting matches to the same EMS agency (OR, 0.74; 95% CI, 0.56-0.99; P = .04) and in instrumental variable probit regression (coefficient, -0.60; 95% CI, -1.04 to -0.16; P < .01).

CONCLUSIONS AND RELEVANCE

In this cohort study, PHND was associated with lower 24-hour mortality compared with emergent trauma center chest tube placement in trauma patients. Although performed rarely, PHND can be a life-saving intervention and should be reinforced in EMS education for appropriately selected trauma patients.

摘要

重要性

院前针减压(PHND)是一种罕见但有潜在救生作用的程序。先前关于创伤患者胸部减压的研究规模较小,仅限于单一机构或紧急医疗服务(EMS)机构,并且缺乏适当的对照组,因此该干预措施的效果不确定。

目的

确定 PHND 与需要紧急胸部减压的患者的早期死亡率之间的关联。

设计、设置和参与者:这是一项回顾性队列研究,从 2000 年 1 月 1 日至 2020 年 3 月 18 日,使用宾夕法尼亚创伤结果研究数据库进行。纳入分析的患者年龄大于 15 岁,从受伤现场被转运。数据分析于 2021 年 4 月 28 日至 2021 年 9 月 18 日进行。

暴露情况

没有接受 PHND 但在到达创伤中心 15 分钟内接受胸腔引流管的患者作为对照组,可能从 PHND 中受益。

主要结果和测量

使用混合效应逻辑回归来确定患者和 EMS 机构因素之间 PHND 的变异性,以及风险调整后 24 小时死亡率与 PHND 之间的关联,同时考虑中心和年份的聚类。进行倾向评分匹配、使用 EMS 机构层面 PHND 比例的工具变量分析以及几项敏感性分析,以解决潜在的偏差。

结果

共纳入 8469 例患者;1337 例(11%)患者接受了 PHND(中位数[IQR]年龄为 37 [25-52]岁;1096 例男性患者[82.0%]),7132 例(84.2%)患者接受了紧急胸腔引流管(中位数[IQR]年龄为 32 [23-48]岁;6083 例男性患者[85.3%])。在研究期间,PHND 率在 0.2%至 0.5%之间保持稳定。患者因素占 PHND 率变化的 43%,而 EMS 机构占 57%。PHND 与 24 小时死亡率降低 25%相关(比值比[OR],0.75;95%CI,0.61-0.94;P = .01)。在存活到急诊科的患者中也发现了类似的结果(OR,0.68;95%CI,0.52-0.89;P < .01),排除严重创伤性脑损伤(OR,0.65;95%CI,0.45-0.95;P = .03),并限制在严重胸部损伤的患者中(OR,0.72;95%CI,0.55-0.93;P = .01)。在进行倾向评分匹配后(OR,0.79;95%CI,0.62-0.98;P = .04),当限制匹配到同一 EMS 机构时(OR,0.74;95%CI,0.56-0.99;P = .04),以及在工具变量概率回归中(系数,-0.60;95%CI,-1.04 至 -0.16;P < .01),PHND 也与 24 小时死亡率降低相关。

结论和相关性

在这项队列研究中,与创伤患者在创伤中心紧急放置胸腔引流管相比,PHND 与 24 小时死亡率降低相关。尽管 PHND 很少进行,但它可以是一种救生干预措施,应在适当选择的创伤患者的 EMS 教育中加强。

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