Hao Wenying, Zhu Chun, Chen Yibo, Li Haibo, Zhu Shufang, Wang Xiaojun
Emergency Department, Ningbo Women and Children's Hospital, No. 339 Liuting Street, Ningbo, Zhejiang, China.
Pediatric Digestionm, Ningbo Women and Children's Hospital, No. 339 Liuting Street, Ningbo, Zhejiang, China.
Evid Based Complement Alternat Med. 2022 Aug 8;2022:3362374. doi: 10.1155/2022/3362374. eCollection 2022.
The aim of this study is to analyze the clinical effect of standardized dietary avoidance therapy on children with cow milk protein allergy (CMPA) and its effect on the intestinal flora.
The clinical data of 200 children with CMPA from our hospital from February 2020 to May 2021 were collected, and they were divided into a study group ( = 100) and a routine group ( = 100) based on different intervention modalities. The routine group received routine treatment, whereas the standardized dietary avoidance therapy was used in the study group. The clinical effects and related intestinal microflora indexes of the two groups were analyzed and compared.
There was no significant difference in the incidence of related symptoms between the two groups before intervention ( > 0.05), and the conditions of the two groups were improved after intervention. The incidences of skin (2%), digestive tract (3.00%), and respiratory tract (1.00%) in the study group were significantly lower than those in the routine group (14.00%, 18.00%, and 11.00%) ( > 0.05). The time taken for complete remission of symptoms and milk tolerance months in the study group (41.23 ± 23.68, 13.28 ± 6.17) were significantly shorter than those in the routine group (145.14 ± 66.74, 16.17 ± 8.05) ( > 0.05). The values of height, weight, and head circumference (HC) of children in the study group (79.88 ± 2.18, 11.09 ± 1.34, 47.88 ± 0.63) were higher than those in the routine group (76.21 ± 2.34, 9.81 ± 1.18, 45.98 ± 0.59) ( > 0.05). The levels of and (9.95 ± 0.89, 11.31 ± 1.05) in the study group were higher than those in the routine group (9.11 ± 0.74, 10.38 ± 0.94), and the levels of yeast-like fungi in the study group (3.08 ± 0.24) were lower than those of the routine group (3.82 ± 0.31) ( > 0.05).
The standardized dietary avoidance therapy is remarkable in the treatment of CMPA, in which the children were able to tolerate ordinary milk earlier, and the intestinal flora was significantly improved, thereby promoting the growth and development of children. It therefore merits clinical promotion.
本研究旨在分析标准化饮食回避疗法对牛奶蛋白过敏（CMPA）患儿的临床疗效及其对肠道菌群的影响。
收集我院2020年2月至2021年5月收治的200例CMPA患儿的临床资料，根据不同干预方式将其分为研究组（n = 100）和常规组（n = 100）。常规组接受常规治疗，研究组采用标准化饮食回避疗法。分析比较两组的临床疗效及相关肠道微生物指标。
干预前两组相关症状发生率比较，差异无统计学意义（P > 0.05），干预后两组病情均有改善。研究组皮肤（2%）、消化道（3.00%）和呼吸道（1.00%）症状发生率显著低于常规组（14.00%、18.00%和11.00%）（P > 0.05）。研究组症状完全缓解时间及牛奶耐受月数（41.23 ± 23.68，13.28 ± 6.17）显著短于常规组（1,45.14 ± 66.74，16.17 ± 8.05）（P > 0.05）。研究组患儿身高、体重和头围（HC）值（79.88 ± 2.18，11.09 ± 1.34，47.88 ± 0.63）高于常规组（76.21 ± 2.34，9.81 ± 1.18，45.98 ± 0.59）（P > 0.05）。研究组双歧杆菌和乳酸杆菌水平（9.95 ± 0.89，11.31 ± 1.05）高于常规组（9.11 ± 0.74，10.38 ± 0.94），研究组酵母样真菌水平（3.08 ± 0.24）低于常规组（3.82 ± 0.31）（P > 0.05）。
标准化饮食回避疗法治疗CMPA效果显著，患儿能更早耐受普通牛奶，肠道菌群明显改善，从而促进患儿生长发育，值得临床推广。
