Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuai fu yuan, Dong Cheng District, Beijing, 100730, China.
Department of Medical Science Research Center, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
BMC Ophthalmol. 2022 Aug 20;22(1):349. doi: 10.1186/s12886-022-02570-0.
This study analyzed regional corneal thickness remodeling, biomechanical properties, and visual outcomes after femtosecond laser-assisted in situ keratomileusis combined with intraoperative accelerated corneal collagen crosslinking (LASIK Xtra) for myopia.
This retrospective study analyzed 21 consecutive patients (18 women, three men; 42 eyes) who were treated with LASIK Xtra. All treatments were performed with ultraviolet-A (energy, 2.7 J/cm; irradiance, 30 mW/cm), using continuous (90 s) illumination. Postoperative values of corneal biometrics and visual outcomes were compared with preoperative values. Corneal thickness changes were evaluated using anterior segment optical coherence tomography. All patients were followed up for 12-month postoperatively. Preoperative and postoperative data were compared statistically using the paired t-test for normally distributed parameters and the Wilcoxon rank-sum test and Friedman analysis of variance with Bonferroni correction for non-normally distributed data.
Uncorrected distance visual acuity (UDVA) significantly improved at 6-month after surgery (P < 0.001). The central and inner regional corneal epithelial thickness significantly increased after LASIK Xtra (P < 0.05 for all), while the peripheral corneal epithelial thickness remained stable at 12-month after surgery. There was also a statistically significant decreased in the stromal thickness at most locations (P < 0.05 for all), except in the outer superior and outer superior-temporal regions.
LASIK Xtra provided improvement in UDVA, corneal curvature, and corneal biomechanical stability. Because the results of this retrospective study results depended on the cohort members' past information, it was inferred and confirmed that regular corneal thickness remodeling occurred after treatment.
本研究分析了飞秒激光辅助原位角膜磨镶术联合术中加速角膜胶原交联（LASIK Xtra）治疗近视后的区域角膜厚度重塑、生物力学特性和视觉效果。
本回顾性研究分析了 21 例连续患者（18 名女性，3 名男性；42 只眼）接受 LASIK Xtra 治疗。所有治疗均采用紫外线-A（能量 2.7 J/cm；辐照度 30 mW/cm），连续（90 s）照射。比较术后角膜生物测量和视觉效果与术前值。使用眼前节光学相干断层扫描评估角膜厚度变化。所有患者均在术后 12 个月进行随访。对于正态分布参数，使用配对 t 检验比较术前和术后数据，对于非正态分布数据，使用 Wilcoxon 秩和检验和 Friedman 方差分析，并使用 Bonferroni 校正。
术后 6 个月未矫正远视力（UDVA）显著提高（P < 0.001）。LASIK Xtra 后中央和内区域角膜上皮厚度显著增加（所有 P < 0.05），而术后 12 个月时周边角膜上皮厚度保持稳定。大多数部位（所有 P < 0.05）的基质厚度也有统计学意义的降低，除外上外侧和上外侧颞区。
LASIK Xtra 可提高 UDVA、角膜曲率和角膜生物力学稳定性。由于本回顾性研究结果取决于队列成员的既往信息，因此推断并证实治疗后角膜厚度会发生规则重塑。
