药物共晶中植物活性成分的研究进展。

Research Progress of Plant Active Ingredients in Pharmaceutical Cocrystal.

机构信息

College of Pharmacy, North China University of Science and Technology, Tangshan 063210, China.

College of Materials Science and Engineering, North China University of Science and Technology, Tangshan 063210, China.

出版信息

Curr Drug Deliv. 2023;20(10):1405-1424. doi: 10.2174/1567201819666220820115950.

DOI:10.2174/1567201819666220820115950

PMID:35993478

Abstract

The disadvantages of active ingredients extracted from medicinal plants due to poor solubility in the body and low bioavailability limit their clinical application. Pharmaceutical cocrystal as a new type of drug in solid form has attracted the attention of researchers. This article reviews the effects of cocrystal in various poorly soluble herbal active ingredients of medicinal plants on their physicochemical properties and biological properties and provides references for the application of pharmaceutical cocrystal in poorly soluble active compounds of medicinal plants.

摘要

由于在体内溶解度差和生物利用度低，从药用植物中提取的有效成分的缺点限制了它们的临床应用。药物共晶作为一种新型的固体药物形式，引起了研究人员的关注。本文综述了共晶对药用植物中各种难溶性植物活性成分的理化性质和生物性质的影响，为药物共晶在药用植物难溶性活性化合物中的应用提供了参考。