姜黄素的抗活性：临床前研究的系统评价。

Anti- Activity of Curcumin: A Systematic Review of Pre-clinical Studies.

机构信息

Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

出版信息

Infect Disord Drug Targets. 2023;23(2):e200822207821. doi: 10.2174/1871526522666220820185637.

DOI:10.2174/1871526522666220820185637

PMID:35996237

Abstract

OBJECTIVE

This study has focused on anti-Toxoplasma gondii activity of curcumin.

METHODS

In this systematic review, anti-parasitic activity of Curcuma longa on Toxoplasma gondii was assessed. Therefore, several databases, including PubMed, Scopus, Web of Science, Embase and Google Scholar, were searched from 2010 to 2020.

RESULTS

Of the 2200 papers retrieved between 2010 and 2020, six articles were reliable and were scrutinized. In 2 in vitro studies, the most used strain was the RH strain of Toxoplasma gondii, whereas among 4 in vivo studies, RH strain was found in 2 (50%) studies, Me49 strain in 1(25%) study, and RH and Me49 strain in 1 (25%) study. In four in vivo studies, the most used animal model was BALB/c, and Swiss albino was found in 1 study (25%) and Albino rats in 1 study (25%).

CONCLUSION

Curcumin and nanoparticles formulated with curcumin are new and useful agents for the treatment of parasitic diseases and reduction of drug resistance. The success of this therapeutic approach stems from the specific action of Curcuma longa against parasites and pathogens.

摘要

目的

本研究集中于姜黄素的抗弓形虫活性。

方法

在本系统评价中，评估了姜黄对弓形虫的抗寄生虫活性。因此，从 2010 年到 2020 年，我们在几个数据库中进行了搜索，包括 PubMed、Scopus、Web of Science、Embase 和 Google Scholar。

结果

在 2010 年至 2020 年期间检索到的 2200 篇论文中，有 6 篇是可靠的，并进行了仔细审查。在 2 项体外研究中，最常使用的菌株是弓形虫 RH 株，而在 4 项体内研究中，RH 株在 2 项研究中（50%），Me49 株在 1 项研究中（25%），RH 和 Me49 株在 1 项研究中（25%）。在 4 项体内研究中，最常用的动物模型是 BALB/c，1 项研究（25%）中使用了瑞士白化病，1 项研究（25%）中使用了白化病大鼠。