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1例患有埃勒斯-当洛综合征患者的早期骨关节炎病例。

A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome.

作者信息

Tran Sydney, Thakkar Radhika, Gillie Monica, Anderson Jeffrey

机构信息

Orthopedic Surgery, St. George's University, St. George, GRD.

Medicine, St. George's University, St. George, GRD.

出版信息

Cureus. 2022 Jul 20;14(7):e27069. doi: 10.7759/cureus.27069. eCollection 2022 Jul.

Abstract

We present a case of early onset osteoarthritis in a patient with Ehlers-Danlos syndrome (EDS) and a history of developmental dysplasia of the hip. Ehlers-Danlos syndrome (EDS) is part of a wide spectrum of connective tissue disorders characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Presentation varies from mild hyperextensibility of the skin and joints to debilitating physical disabilities and vascular complications because of genetic defects in type one and three collagen synthesis. Collagen is the most abundant protein in nearly all parts of the body and errors in the production of this protein have widespread effects. Therefore, we suggest a multidisciplinary approach to the management of patients with EDS, with an emphasis on patient education, to aid in the prevention and early detection of complications.

摘要

我们报告一例患有埃勒斯-当洛综合征(EDS)且有髋关节发育不良病史的患者发生的早发性骨关节炎。埃勒斯-当洛综合征(EDS)是一系列广泛的结缔组织疾病的一部分,其特征为皮肤过度伸展、关节活动过度和组织脆弱。临床表现从皮肤和关节的轻度过度伸展到因I型和III型胶原蛋白合成的基因缺陷导致的使人衰弱的身体残疾和血管并发症不等。胶原蛋白是人体几乎所有部位中含量最丰富的蛋白质,这种蛋白质产生过程中的错误会产生广泛影响。因此,我们建议采用多学科方法来管理EDS患者,重点是患者教育,以帮助预防和早期发现并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d162/9390864/0501fc750909/cureus-0014-00000027069-i01.jpg

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