宏基因组下一代测序技术恢复了 B 细胞耗竭罕见感染并发症的诊断。
Metagenomic next-generation sequencing restores the diagnosis of a rare infectious complication of B cell depletion.
机构信息
Department of Clinical Immunopathology, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, 1, Avenue Claude Vellefaux, 75010, Paris, France.
Université de Paris, Paris, France.
出版信息
Eur J Clin Microbiol Infect Dis. 2022 Oct;41(10):1269-1273. doi: 10.1007/s10096-022-04484-7. Epub 2022 Aug 24.
A 45-year-old female patient receiving rituximab for B cell non-Hodgkin follicular lymphoma presented unexplained recurrent fever, abdominal discomfort, and pollakiuria. We performed shotgun metagenomic sequencing from peri-kidney collection that identified a co-infection with Mycoplasma hominis and Ureaplasma urealyticum. The patient recovered with sequelae after appropriate antibiotic treatment was given.
一位 45 岁女性患者因 B 细胞非霍奇金滤泡性淋巴瘤接受利妥昔单抗治疗，出现不明原因的反复发热、腹部不适和多尿。我们对肾周采集物进行了鸟枪法宏基因组测序，鉴定出合并感染了人型支原体和解脲脲原体。患者经适当的抗生素治疗后痊愈，但留有后遗症。
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