School of Physics, University of Melbourne, Melbourne, Victoria, Australia.
Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok City, Indonesia.
J Appl Clin Med Phys. 2023 Jan;24(1):e13756. doi: 10.1002/acm2.13756. Epub 2022 Aug 24.
The lack of equitable access to radiotherapy (RA) linear accelerators (LINACs) is a substantial barrier to cancer care in low- and middle-income countries (LMICs). These nations are expected to bear up to 75% of cancer-related deaths globally by 2030. State-of-the-art LINACs in LMICs experience major issues in terms of robustness, with mechanical and electrical breakdowns resulting in downtimes ranging from days to months. While existing research has identified the higher failure frequency and downtimes between LMICs (Nigeria, Botswana) compared to high-income countries (HICs, the UK), there has been a need for additional data and study particularly relating to multileaf collimators (MLCs).
This study presents for the first time the analysis of data gathered through a dedicated survey and workshop including participants from 14 Indonesian hospitals, representing a total of 19 LINACs. We show the pathways to failure of radiotherapy LINACs and frequency of breakdowns with a focus on the MLC subsystem.
This dataset shows that LINACs throughout Indonesia are out of operation for seven times longer than HICs, and the mean time between failures of a LINAC in Indonesia is 341.58 h or about 14 days. Furthermore, of the LINACs with an MLC fitted, % of all mechanical faults are due to the MLC, and % of cases requiring a replacement component are related to the MLC.
These results highlight the pressing need to improve robustness of RT technology for use in LMICs, highlighting the MLC as a particularly problematic component. This work motivates a reassessment of the current generation of RT LINACs and demonstrates the need for dedicated efforts toward a future where cancer treatment technology is robust for use in all environments where it is needed.
在中低收入国家(LMICs),公平获得放射治疗(RT)线性加速器(LINACs)的机会有限,这是癌症治疗的一个重大障碍。到 2030 年,这些国家预计将承担全球多达 75%的癌症相关死亡。在 LMICs,最先进的 LINACs 在稳健性方面存在重大问题,机械和电气故障导致停机时间从几天到几个月不等。虽然现有研究已经确定了与高收入国家(HICs,英国)相比,LMICs(尼日利亚、博茨瓦纳)的 LINAC 故障频率和停机时间更高,但还需要更多的数据和研究,特别是与多叶准直器(MLCs)有关。
本研究首次分析了通过专门的调查和研讨会收集的数据,参与者来自 14 家印度尼西亚医院,共代表 19 台 LINAC。我们展示了 RT LINAC 故障的途径和故障频率,重点是 MLC 子系统。
该数据集显示,印度尼西亚的 LINAC 停机时间比 HIC 长 7 倍,印度尼西亚的 LINAC 平均故障间隔时间为 341.58 小时,约为 14 天。此外,装有 MLC 的 LINAC 中,%的机械故障是由于 MLC 引起的,%的需要更换部件的情况与 MLC 有关。
这些结果突出表明迫切需要提高 RT 技术在 LMICs 中的稳健性,突出 MLC 是一个特别有问题的组件。这项工作促使对当前一代 RT LINACs 进行重新评估,并证明需要专门努力,以确保未来癌症治疗技术在所有需要的环境中都具有稳健性。