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水果的植物化学分析、抗氧化、抗癌和抗炎活性

Phytochemical analysis, antioxidant, anticancer and anti-inflammatory activities of fruits.

作者信息

Mejri Houda, Ouerghemi Ines, Aidi Wannes Wissem, Haddada Faouzia Mahjoub, Tlili Nizar, Hammami Majdi, Dussault Catherine, Girad-La Lancette Karl, Pichette André, Legault Jean, Saidani-Tounsi Moufida

机构信息

Laboratory of Aromatic and Medicinal Plants, Borj Cedria Biotechnology Center, Hammam-Lif, Tunisia.

Laboratoire LASEVE, Université du Québec a Chicoutimi, Saguenay, Canada.

出版信息

Int J Environ Health Res. 2023 Dec;33(12):1676-1685. doi: 10.1080/09603123.2022.2115469. Epub 2022 Aug 24.

Abstract

is used as a medicinal herb in many countries. In this study, cyclohexane, dichloromethane, ethyl acetate, methanol and water were used as solvents in the extraction of fruits. The contents of total phenolics, total flavonoids, total tannins and condensed tannins as well as the biological activities of these extracts were investigated using various and assays. Results showed that all solvent extracts of had no anticancer activity against cancerous (A-549 and DLD-1) and non-cancerous (WS-1) human cells. Methanol and ethyl acetate were the most effective solvent for extraction of phenolic compounds and also exhibited the highest antioxidant and anti-inflammatory activities. The methanol extract of fruits was the richest in phenolic compounds with the predominance of ferulic acid, catechin and narengin. These results supported the use of fruit as natural source of bioactive compound for pharmaceutical applications.

摘要

在许多国家被用作药草。在本研究中,环己烷、二氯甲烷、乙酸乙酯、甲醇和水被用作提取果实的溶剂。使用各种方法和分析来研究总酚、总黄酮、总单宁和缩合单宁的含量以及这些提取物的生物活性。结果表明,该植物的所有溶剂提取物对癌性(A - 549和DLD - 1)和非癌性(WS - 1)人类细胞均无抗癌活性。甲醇和乙酸乙酯是提取酚类化合物最有效的溶剂,并且还表现出最高的抗氧化和抗炎活性。该植物果实的甲醇提取物中酚类化合物含量最丰富,主要成分是阿魏酸、儿茶素和橙皮苷。这些结果支持将该植物果实作为药物应用中生物活性化合物的天然来源。

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