颅内动脉瘤的孤子风箱模型
Solitonic Windkessel Model for Intracranial Aneurysm.
作者信息
Ujiie Hiroshi, Iwata Yoritaka
机构信息
Department of Neurosurgery, Kamagaya General Hospital, Chiba 273-0121, Japan.
Ujiie Neurosurgical and Medical Clinic, Chiyoda-ku, Tokyo 102-0094, Japan.
出版信息
Brain Sci. 2022 Jul 31;12(8):1016. doi: 10.3390/brainsci12081016.
The Windkessel model, which is known as a successful model for explaining the hemodynamic circulation, is a mathematical model with a direct correspondence with the electric circuit. We propose a theoretical model for the intracranial aneurysm based on the Windkessel-type steady blood flow. Intracranial aneurysms are well known vascular lesions, which cause subarachnoid hemorrhages. Since an aneurysm is an end-sack formed on the blood vessel, it functions as an unusual blood path that has characteristic features such as a reservoir and bottle neck orifice. We simulate an aneurysm by an electric circuit consisting of three different impedances, resistance, capacitance and inductance. A dumbbell-shaped aneurysm is the most dangerous aneurysm to easily rupture. Our aneurysmal model is created as a two-story aneurysm model for this point, thus namely the five-element Windkessel. Then, the mathematical formula was solved in numerical simulations by changing the size of the aneurysm and the elasticity of the aneurysm wall. An analysis of this model provided that the presence of the daughter aneurysm and the thinning of the aneurysm wall are positively correlated with a sharp increase in blood pressure in the aneurysm dome. Our mathematic aneurysm model proposes a good analogue to the real aneurysm and proved that this model includes soliton that is a non-decreasing wave propagation.
风箱模型是一种成功解释血液动力学循环的模型,它是一种与电路直接对应的数学模型。我们基于风箱型稳定血流提出了一种颅内动脉瘤的理论模型。颅内动脉瘤是众所周知的血管病变,可导致蛛网膜下腔出血。由于动脉瘤是在血管上形成的囊袋,它起到了异常血液通道的作用,具有诸如储存器和瓶颈孔等特征。我们通过由电阻、电容和电感三种不同阻抗组成的电路来模拟动脉瘤。哑铃形动脉瘤是最容易破裂的危险动脉瘤。基于这一点,我们的动脉瘤模型被创建为两层动脉瘤模型,即五元风箱模型。然后,通过改变动脉瘤的大小和动脉瘤壁的弹性,在数值模拟中求解数学公式。对该模型的分析表明,子动脉瘤的存在和动脉瘤壁的变薄与动脉瘤穹顶处血压的急剧升高呈正相关。我们的数学动脉瘤模型为真实动脉瘤提供了一个很好的类比,并证明该模型包含孤子,即一种非衰减波传播。