抗精神病药物所致帕金森症的病理生理机制

Pathophysiological Mechanisms of Antipsychotic-Induced Parkinsonism.

作者信息

Vaiman Elena E, Shnayder Natalia A, Khasanova Aiperi K, Strelnik Anna I, Gayduk Arseny J, Al-Zamil Mustafa, Sapronova Margarita R, Zhukova Natalia G, Smirnova Daria A, Nasyrova Regina F

机构信息

V. M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Institute of Personalized Psychiatry and Neurology, 192019 St. Petersburg, Russia.

Shared Core Facilities Molecular and Cell Technologies, V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia.

出版信息

Biomedicines. 2022 Aug 18;10(8):2010. doi: 10.3390/biomedicines10082010.

Among neurological adverse reactions in patients with schizophrenia treated with antipsychotics (APs), drug-induced parkinsonism (DIP) is the most common motility disorder caused by drugs affecting dopamine receptors. One of the causes of DIP is the disruption of neurotransmitter interactions that regulate the signaling pathways of the dopaminergic, cholinergic, GABAergic, adenosinergic, endocannabinoid, and other neurotransmitter systems. Presently, the development mechanisms remain poorly understood despite the presence of the considered theories of DIP pathogenesis.