尿白细胞介素-6 是犬急性肾损伤有潜在应用价值的诊断和预后标志物。

Urinary interleukin-6 is a potentially useful diagnostic and prognostic marker of acute kidney injury in dogs.

机构信息

Small Animal Internal Medicine Department, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.

出版信息

Vet Rec. 2022 Oct;191(8):e2079. doi: 10.1002/vetr.2079. Epub 2022 Aug 27.

DOI:10.1002/vetr.2079

PMID:36030370

Abstract

BACKGROUND

Interleukin-6 (IL6) is a pro-inflammatory cytokine implicated in the pathophysiology of urinary tract diseases. The objective of this study was to evaluate the diagnostic and prognostic utilities of urinary IL6 (uIL6) in dogs with acute kidney injury (AKI) and other urinary tract diseases.

METHODS

Eighty client-owned dogs were included and divided into four groups: AKI, chronic kidney disease (CKD), urinary tract infection and healthy controls. Urine samples were analysed for uIL6 and normalised to urinary creatinine (uIL6/uCr).

RESULTS

Dogs in the AKI group had higher uIL6/uCr compared with the control and CKD groups (p < 0.001 and 0.012, respectively). Receiver operator characteristic (ROC) curve analysis of uIL6/uCr as a diagnostic marker for AKI had an area under the curve (AUC) of 0.91 (95% confidence interval [CI], 0.81-1.0) with 82% sensitivity and 90% specificity (cutoff point 4.5 pg/mg) when including the AKI and control groups. ROC analysis including AKI compared with all other groups had an AUC of 0.77 (95% CI, 0.67-0.87) for the diagnosis of AKI with sensitivity and specificity of 71% and 78%, respectively (cutoff point 10.4 pg/mg). The 30-day mortality of the AKI group was 34%, and there was no difference in uIL6/uCr between survivors and non-survivors of AKI.

CONCLUSIONS

uIL6/uCr is a potentially sensitive and specific diagnostic marker for AKI in dogs.

摘要

背景

白细胞介素-6（IL-6）是一种促炎细胞因子，与尿路感染疾病的病理生理学有关。本研究旨在评估尿液白细胞介素 6（uIL-6）在患有急性肾损伤（AKI）和其他尿路感染疾病的犬中的诊断和预后价值。

方法

纳入 80 只患犬，并将其分为 4 组：AKI 组、慢性肾病（CKD）组、尿路感染组和健康对照组。分析尿液样本中的 uIL-6 并与尿肌酐（uIL-6/uCr）进行归一化。

结果

与对照组和 CKD 组相比，AKI 组犬的 uIL-6/uCr 更高（p<0.001 和 0.012）。uIL-6/uCr 作为 AKI 诊断标志物的受试者工作特征（ROC）曲线分析，在包括 AKI 和对照组时，曲线下面积（AUC）为 0.91（95%置信区间 [CI]，0.81-1.0），敏感性为 82%，特异性为 90%（截断值为 4.5 pg/mg）。ROC 分析包括 AKI 与所有其他组相比，AKI 的 AUC 为 0.77（95% CI，0.67-0.87），敏感性和特异性分别为 71%和 78%（截断值为 10.4 pg/mg）。AKI 组的 30 天死亡率为 34%，且 AKI 存活者和非存活者的 uIL-6/uCr 无差异。