Francis Beverly R, Challen Laura M
PGY-1 Pharmacy Resident, St. Louis College of Pharmacy, University of Health Sciences & Pharmacy.
Associate Professor, Department of Pharmacy Practice, St. Louis College of Pharmacy, University of Health Sciences & Pharmacy.
Innov Pharm. 2021 Sep 22;12(4). doi: 10.24926/iip.v12i4.4356. eCollection 2021.
: At an Internal Medicine outpatient clinic, patients are referred to a weight loss service by their primary care physician to be managed by a clinical pharmacist and dietician. . : This was a retrospective, single-center, cohort study including adults ≥18 years of age with BMI ≥30 or BMI ≥27 with at least one weight-related comorbidity such as hypertension, dyslipidemia, or type 2 diabetes mellitus, and referred to the clinic's weight loss service or managed by their primary care physician. The primary outcome was percent weight loss from baseline. Key secondary outcomes included number of patients who had >5% weight loss in 6 months, number of patients who received liraglutide after 6 months, and percent weight loss in patients prescribed liraglutide. Statistical analysis included descriptive statistics, t-test for continuous outcomes, and chi-square test for between-group differences. : A total of 86 patients met inclusion criteria with 43 patients in the weight loss service group (intervention) and 43 patients in the primary care group (standard care). The intervention group had a significantly higher baseline weight and BMI than the standard care group (120.44 kg vs. 95.72 kg, p <0.001 and 45.34 kg/m vs. 37.62 kg/m, p <0.001 respectively). The percent change in weight from baseline in the intervention group was a decrease of 3% compared to a decrease of 0.35% in the standard care group (p=0.03). : Involvement of clinical pharmacist in interdisciplinary weight loss management through pharmacotherapy and other medication related services, shows considerable improvement in weight loss, when compared to the standard care of weight management. However, prospective randomized studies are warranted to further assess the benefits of a pharmacist-driven, interdisciplinary weight loss service.
在内科门诊,患者由其初级保健医生转介至体重管理服务部门,由临床药剂师和营养师进行管理。
这是一项回顾性、单中心队列研究,纳入年龄≥18岁、BMI≥30或BMI≥27且至少有一种与体重相关的合并症(如高血压、血脂异常或2型糖尿病)的成年人,这些患者被转介至该诊所的体重管理服务部门或由其初级保健医生管理。主要结局是相对于基线的体重减轻百分比。关键次要结局包括6个月内体重减轻超过5%的患者数量、6个月后接受利拉鲁肽治疗的患者数量以及接受利拉鲁肽治疗患者的体重减轻百分比。统计分析包括描述性统计、连续结局的t检验以及组间差异的卡方检验。
共有86名患者符合纳入标准,其中43名患者在体重管理服务组(干预组),43名患者在初级保健组(标准治疗组)。干预组的基线体重和BMI显著高于标准治疗组(分别为120.44kg对95.72kg,p<0.001;45.34kg/m对37.62kg/m,p<0.001)。干预组相对于基线的体重变化百分比下降了3%,而标准治疗组下降了0.35%(p=0.03)。
与体重管理的标准治疗相比,临床药剂师通过药物治疗和其他与药物相关的服务参与多学科体重管理,显示出体重减轻有显著改善。然而,需要进行前瞻性随机研究以进一步评估药剂师主导的多学科体重管理服务的益处。