Sabag Maya, Geva Ronny
Department of Psychology, Bar-Ilan University, Ramat Gan, Israel.
The Developmental Neuropsychology Lab, The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.
Front Hum Neurosci. 2022 Aug 11;16:902041. doi: 10.3389/fnhum.2022.902041. eCollection 2022.
Children with autism spectrum disorder (ASD) experience a range of social and non-social attention deficits. To date, most studies assessed the neurological framework or discrete behavioral traits related to one attention network, leaving a gap in the understanding of the developmental cascade affecting the inter-relations among attention networks in ASD in a pervasive manner. We propose a theoretical framework that integrates the behavioral deficits and neurological manifestations through a cohesive developmental prism of attention networks' activations while assessing their impact on social deficits in children with ASD. Insights arising from the model suggest hyper-and-hypoactivation of posterior attention networks leads to an altered prefrontal anterior attention network weight in ways that conjointly impact social performance in ASD. This perspective on how attention networks develop and interact in ASD may inform future research directions regarding ASD and attention development.
患有自闭症谱系障碍（ASD）的儿童存在一系列社交和非社交注意力缺陷。迄今为止，大多数研究评估的是与一个注意力网络相关的神经学框架或离散行为特征，在全面理解影响ASD中注意力网络之间相互关系的发育级联方面存在空白。我们提出了一个理论框架，该框架通过注意力网络激活的连贯发育棱镜整合行为缺陷和神经学表现，同时评估它们对ASD儿童社交缺陷的影响。该模型得出的见解表明，后注意力网络的过度激活和低激活会导致前额叶前注意力网络权重发生改变，从而共同影响ASD的社交表现。这种关于ASD中注意力网络如何发育和相互作用的观点可能为未来关于ASD和注意力发展的研究方向提供信息。
