Blockley Alix, Ogle Daisy, Woodrow Charlie, Montealegre-Z Fernando, Warren Ben
College of Life Sciences, University of Leicester, Leicester LE1 7RH, UK.
School of Life Sciences, University of Lincoln, Joseph Banks Laboratories, Lincoln LN6 7DL, UK.
iScience. 2022 Jul 21;25(9):104746. doi: 10.1016/j.isci.2022.104746. eCollection 2022 Sep 16.
Hearing loss is not unique to humans and is experienced by all animals in the face of wild and eclectic differences in ear morphology. Here, we exploited the high throughput and accessible tympanal ear of the desert locust, to rigorously quantify changes in the auditory system due to noise exposure and age. In this exploratory study, we analyzed tympanal displacements, morphology of the auditory Müller's organ and measured activity of the auditory nerve, the transduction current, and electrophysiological properties of individual auditory receptors. This work shows that hearing loss manifests as a complex disorder due to differential effects of age and noise on several processes and cell types within the ear. The "middle-aged deafness" pattern of hearing loss found in locusts mirrors that found for humans exposed to noise early in their life suggesting a fundamental interaction of the use of an auditory system (noise) and its aging.
听力损失并非人类所独有，面对耳朵形态的巨大差异，所有动物都会经历听力损失。在这里，我们利用沙漠蝗虫高通量且易于研究的鼓膜耳，严格量化了噪声暴露和年龄导致的听觉系统变化。在这项探索性研究中，我们分析了鼓膜位移、听觉米勒氏器官的形态，并测量了听觉神经的活动、转导电流以及单个听觉感受器的电生理特性。这项工作表明，由于年龄和噪声对耳朵内多个过程和细胞类型的不同影响，听力损失表现为一种复杂的病症。在蝗虫中发现的“中年失聪”听力损失模式与早年暴露于噪声的人类相似，这表明听觉系统的使用（噪声）及其老化之间存在基本的相互作用。
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