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一名患有系统性红斑狼疮的年轻男性的自发性冠状动脉夹层与动脉粥样硬化:病例报告及文献综述

Spontaneous coronary artery dissection and atherosclerosis in a young man with systemic lupus erythematosus: A case report and literature review.

作者信息

Huang Hongbo, Ma Xiaojuan, Xu Linjie, Wang Xin, Shi Dazhuo, Zhao Fuhai, Zhang Ying

机构信息

Graduate School of Beijing University of Chinese Medicine, Beijing, China.

National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

出版信息

Front Cardiovasc Med. 2022 Aug 10;9:951188. doi: 10.3389/fcvm.2022.951188. eCollection 2022.

Abstract

BACKGROUND

Spontaneous coronary artery dissection (SCAD) is a rare coronary artery disease that frequently occurs in young, female patients without risk factors, and conservative treatment is often recommended for its management. The patient reported here is a male patient with systemic lupus erythematosus (SLE).

CASE SUMMARY

We described a 28-year-old man with SLE who presented with acute ST-segment elevation myocardial infarction (STEMI), and was diagnosed with SCAD through a long dissection of the left anterior descending branch (LAD) by coronary angiography. The patient was treated with percutaneous coronary intervention (PCI) with stent implantation. Ten years later, he developed in-stent stenosis and other coronary atherosclerosis and was retreated with PCIs. Based on this case and according to the literature review, the existing treatment and prognosis of SLE with spontaneous coronary artery dissection and atherosclerosis are discussed.

CONCLUSION

Cardiovascular complications should be considered in patients with systemic lupus erythematosus, although they may not initially be atherosclerotic diseases. Attention should be paid to distinguish spontaneous coronary dissection in order to minimize missed or delayed diagnoses and take appropriate managements, as well as the development of atherosclerosis in SLE patients, and timely intervention has a better prognosis.

摘要

背景

自发性冠状动脉夹层(SCAD)是一种罕见的冠状动脉疾病,常发生于无危险因素的年轻女性患者,其治疗通常推荐采用保守治疗。本文报道的患者是一名患有系统性红斑狼疮(SLE)的男性患者。

病例摘要

我们描述了一名28岁患有SLE的男性患者,其表现为急性ST段抬高型心肌梗死(STEMI),通过冠状动脉造影发现左前降支(LAD)存在长段夹层而被诊断为SCAD。该患者接受了经皮冠状动脉介入治疗(PCI)并植入支架。十年后,他出现了支架内狭窄及其他冠状动脉粥样硬化病变,并再次接受了PCI治疗。基于该病例并结合文献复习,对SLE合并自发性冠状动脉夹层及动脉粥样硬化的现有治疗方法及预后进行了讨论。

结论

系统性红斑狼疮患者应考虑心血管并发症,尽管其最初可能并非动脉粥样硬化性疾病。应注意鉴别自发性冠状动脉夹层,以尽量减少漏诊或延误诊断,并采取适当的治疗措施,同时还应关注SLE患者动脉粥样硬化的发生发展,及时干预预后更佳。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44ee/9402264/713de380d0db/fcvm-09-951188-g0001.jpg

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