Llorente-González Clara, González-Rodríguez Marta, Vicente-Manzanares Miguel
Molecular Mechanisms Program, Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, 37007 Salamanca, Spain.
Explor Target Antitumor Ther. 2021;2(3):292-308. doi: 10.37349/etat.2021.00047. Epub 2021 Jun 28.
Phosphorylation of cytoskeletal proteins regulates the dynamics of polymerization, stability, and disassembly of the different types of cytoskeletal polymers. These control the ability of cells to migrate and divide. Mutations and alterations of the expression levels of multiple protein kinases are hallmarks of most forms of cancer. Thus, altered phosphorylation of cytoskeletal proteins is observed in most cancer cells. These alterations potentially control the ability of cancer cells to divide, invade and form distal metastasis. This review highlights the emergent role of phosphorylation in the control of the function of the different cytoskeletal polymers in cancer cells. It also addresses the potential effect of targeted inhibitors in the normalization of cytoskeletal function.
细胞骨架蛋白的磷酸化调节不同类型细胞骨架聚合物的聚合、稳定性和解聚动态。这些过程控制细胞迁移和分裂的能力。多种蛋白激酶的突变和表达水平改变是大多数癌症形式的标志。因此，在大多数癌细胞中都观察到细胞骨架蛋白磷酸化的改变。这些改变可能控制癌细胞的分裂、侵袭和形成远处转移的能力。本综述强调了磷酸化在控制癌细胞中不同细胞骨架聚合物功能方面的新作用。它还探讨了靶向抑制剂对细胞骨架功能正常化的潜在影响。
