PDZK1IP1基因促进甲状腺乳头状癌的增殖、迁移和侵袭。
PDZK1IP1 gene promotes proliferation, migration, and invasion in papillary thyroid carcinoma.
作者信息
Zhang Wei, Zheng Danni, Jin Lingli, Hirachan Suzita, Bhandari Adheesh, Li Yulian, Chen Buran, Lu Yiqiao, Wen Jialiang, Lin Bangyi, Zhang Xiaohua, Chen Chengze
机构信息
Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
Department of General Surgery, Breast and Thyroid Unit, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
出版信息
Pathol Res Pract. 2022 Oct;238:154091. doi: 10.1016/j.prp.2022.154091. Epub 2022 Aug 27.
Thyroid cancer is a common malignant tumor for the adult and the potential molecular mechanism of papillary thyroid cancer cell metastasis is still unclear. We used sequencing techniques to analyze paired papillary thyroid carcinoma (PTC) and adjacent thyroid tissue and identified a gene, PDZK1IP1, that was significantly overexpressed in thyroid cancer. We found It has been detected to play an important role in many malignant tumors. But the role in papillary thyroid cancer was still unknown, we decided to find a new marker and therapeutic target for the disease. The present study shows that PDZK1IP1 may be a potential gene that leads to thyroid cancer. In our study, silencing PDZK1IP1 can inhibit PTC cell proliferation, migration, invasion, apoptosis, and cell cycle arrest. This study surmised that PDZK1IP1 was an oncogene that correlated with tumor development.
甲状腺癌是成人常见的恶性肿瘤，甲状腺乳头状癌细胞转移的潜在分子机制仍不清楚。我们使用测序技术分析配对的甲状腺乳头状癌（PTC）和相邻甲状腺组织，鉴定出一个基因PDZK1IP1，其在甲状腺癌中显著过表达。我们发现它已被检测到在许多恶性肿瘤中起重要作用。但它在甲状腺乳头状癌中的作用仍不清楚，我们决定为该疾病寻找新的标志物和治疗靶点。本研究表明，PDZK1IP1可能是导致甲状腺癌的潜在基因。在我们的研究中，沉默PDZK1IP1可抑制PTC细胞增殖、迁移、侵袭、凋亡和细胞周期停滞。本研究推测PDZK1IP1是一个与肿瘤发展相关的癌基因。
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