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痴呆患者激越行为的精神药物治疗:如果指南推荐的治疗建议不够充分怎么办?一项定性研究。

Psychotropic drug treatment for agitated behaviour in dementia: what if the guideline prescribing recommendations are not sufficient? A qualitative study.

机构信息

Department of Medicine for Older People, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Amsterdam Public Health, Aging & Later Life, Amsterdam, The Netherlands.

出版信息

Age Ageing. 2022 Sep 2;51(9). doi: 10.1093/ageing/afac189.

Abstract

BACKGROUND

Agitation is a common challenging behaviour in dementia with a negative influence on patient's quality of life and a high caregiver burden. Treatment is often difficult. Current guidelines recommend restrictive use of psychotropic drug treatment, but guideline recommendations do not always suffice.

OBJECTIVE

To explore how physicians decide on psychotropic drug treatment for agitated behaviour in dementia when the guideline prescribing recommendations are not sufficient.

METHODS

We conducted five online focus groups with a total of 22 elderly care physicians, five geriatricians and four old-age psychiatrists, in The Netherlands. The focus groups were thematically analysed.

RESULTS

We identified five main themes. Transcending these themes, in each of the focus groups physicians stated that there is 'not one size that fits all'. The five themes reflect physicians' considerations when deciding on psychotropic drug treatment outside the guideline prescribing recommendations for agitated behaviour in dementia: (1) 'reanalysis of problem and cause', (2) 'hypothesis of underlying cause and treatment goal', (3) 'considerations regarding drug choice', (4) 'trial and error' and (5) 'last resort: sedation'.

CONCLUSION

When guideline prescribing recommendations do not suffice, physicians start with reanalysing potential underlying causes. They try to substantiate and justify medication choices as best as they can with a hypothesis of underlying causes or treatment goal, using other guidelines, and applying personalised psychotropic drug treatment.

摘要

背景

激越行为是痴呆患者常见的挑战性行为,对患者的生活质量产生负面影响,并给照料者带来沉重负担。治疗通常较为困难。目前的指南建议谨慎使用精神药物治疗,但指南推荐并不总是足够的。

目的

当指南规定的建议不足时,探讨医生如何决定对痴呆患者激越行为进行精神药物治疗。

方法

我们在荷兰进行了五组在线焦点小组讨论,共有 22 名老年护理医生、五名老年病学家和四名老年精神病学家参加。对焦点小组进行了主题分析。

结果

我们确定了五个主要主题。在每个焦点小组中,医生都表示超越这些主题,“没有一种方法适用于所有人”。这五个主题反映了医生在决定痴呆患者激越行为的精神药物治疗时超出指南规定建议的考虑因素:(1)“重新分析问题和原因”,(2)“潜在原因和治疗目标的假设”,(3)“药物选择的考虑”,(4)“尝试和错误”,(5)“最后手段:镇静”。

结论

当指南规定的建议不足时,医生首先重新分析潜在的根本原因。他们试图通过潜在原因或治疗目标的假设来尽可能合理地证明药物选择,并参考其他指南,并应用个性化的精神药物治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee0/9441198/b732c61e1477/afac189f1.jpg

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