Engstrom Amanda K, Davis Caroline D, Erichsen Jason L, Mondoux Michelle A
Department of Biology, College of the Holy Cross, Worcester, MA, USA.
MicroPubl Biol. 2022 Aug 16;2022. doi: 10.17912/micropub.biology.000614. eCollection 2022.
Human metabolic diseases and high-sugar diets have been associated with infertility. Previous studies show that high-glucose diet also affects fertility in leading to decreased offspring production and delayed reproductive timing. We tested whether the timing of glucose exposure affects these fertility defects or the embryo to larval transition. We found that decreased offspring production was strictly a response to high-glucose exposure in adulthood, whereas the delayed reproductive profile was influenced by both developmental and adult diets. We found no effect of high-glucose diet on the number of embryos that develop to the first larval stage. Together, these results suggest that the decreased offspring production and delayed reproductive profile may be separable phenotypes, and that a high-glucose diet reduces the number of offspring by interfering with processes regulated during adulthood.
人类代谢疾病和高糖饮食与不孕不育有关。先前的研究表明，高糖饮食也会影响生育能力，导致后代数量减少和生殖时间延迟。我们测试了葡萄糖暴露的时间是否会影响这些生育缺陷或胚胎到幼虫的转变。我们发现，后代数量减少严格来说是成年期高糖暴露的结果，而生殖时间延迟则受发育和成年期饮食的共同影响。我们发现高糖饮食对发育到第一幼虫阶段的胚胎数量没有影响。总之，这些结果表明，后代数量减少和生殖时间延迟可能是可分离的表型，并且高糖饮食通过干扰成年期调节的过程来减少后代数量。
