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针刺治疗与偏头痛患者痴呆风险降低相关:一项基于真实世界数据的倾向评分匹配队列研究。

Acupuncture Treatment is Associated with Reduced Dementia Risk in Patients with Migraine: A Propensity-Score-Matched Cohort Study of Real-World Data.

作者信息

Huang Cheng-Hao, Lin Mei-Chen, Chou I-Ching, Hsieh Ching-Liang

机构信息

Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung City, 40402, Taiwan.

Department of Chinese Medicine, China Medical University Hospital, Taichung City, 40447, Taiwan.

出版信息

Neuropsychiatr Dis Treat. 2022 Aug 30;18:1895-1906. doi: 10.2147/NDT.S372076. eCollection 2022.

Abstract

BACKGROUND

Migraine is a recurrent headache disease that has been identified as a risk factor for subsequent dementia. The present study collected data from Taiwan's National Health Insurance Research Database (NHIRD) to investigate the incidence of dementia in patients with migraine who did or did not concurrently receive acupuncture treatment.

METHODS

A 1:1 propensity score method was used to match an equal number of patients (N = 4813) in the acupuncture and nonacupuncture cohorts based on sex, age, migraine diagnosis year, index year, insurance amount, urbanization level, baseline comorbidities, and medication usage. We employed Cox proportional hazards models to evaluate the risk of dementia.

RESULTS

Patients with migraine who received acupuncture treatment were found to have a lower risk of dementia (adjusted hazard ratio [aHR] = 0.51, 95% CI = 0.40-0.65) than those who did not undergo acupuncture treatment. The cumulative incidence of dementia was significantly lower in the acupuncture cohort than in the nonacupuncture cohort (Log rank test, < 0.001). This propensity score-matched cohort study demonstrated an association between acupuncture treatment and dementia development in patients with migraine in Taiwan.

CONCLUSION

The results suggest that acupuncture treatment significantly reduced the development of dementia in patients with migraine.

摘要

背景

偏头痛是一种复发性头痛疾病,已被确定为后续患痴呆症的风险因素。本研究从台湾国民健康保险研究数据库(NHIRD)收集数据,以调查接受或未同时接受针灸治疗的偏头痛患者患痴呆症的发生率。

方法

采用1:1倾向评分法,根据性别、年龄、偏头痛诊断年份、索引年份、保险金额、城市化水平、基线合并症和用药情况,对针灸组和非针灸组中数量相等的患者(N = 4813)进行匹配。我们使用Cox比例风险模型来评估患痴呆症的风险。

结果

发现接受针灸治疗的偏头痛患者患痴呆症的风险低于未接受针灸治疗的患者(调整后风险比[aHR] = 0.51,95%置信区间 = 0.40 - 0.65)。针灸组痴呆症的累积发生率显著低于非针灸组(对数秩检验,< 0.001)。这项倾向评分匹配队列研究表明,台湾偏头痛患者的针灸治疗与痴呆症发展之间存在关联。

结论

结果表明,针灸治疗显著降低了偏头痛患者患痴呆症的发生率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4358/9440707/e68970490cca/NDT-18-1895-g0001.jpg

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