氨甲环酸在手术安全中的应用：时不我待。
Tranexamic acid for safer surgery: the time is now.
机构信息
Royal College of Anaesthetists, London, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton/University of Southampton, Southampton, UK.
NHS Blood and Transplant, Oxford University Hospitals NHS Foundation Trust and the University of Oxford, Oxford, UK.
出版信息
Br J Anaesth. 2022 Oct;129(4):459-461. doi: 10.1016/j.bja.2022.06.024. Epub 2022 Sep 5.
Tranexamic acid reduces surgical bleeding. Consistent with previous research, the POISE-3 (Peri-Operative Ischemic Evaluation-3) trial found that tranexamic acid reduces major bleeding by 25% and with a low probability of any increase in thromboembolic events. Wider tranexamic acid use will improve surgical safety, avoid unnecessary blood use, reduce the risk of transfusion transmitted infections, and save healthcare funds. 'Consideration of tranexamic acid use' should be included in the safe surgery checklist. We have the evidence, and we need to act on it.
氨甲环酸可减少手术出血。与先前的研究一致，POISE-3（围手术期局部缺血评估-3）试验发现氨甲环酸可将主要出血减少 25%，且血栓栓塞事件发生的可能性较低。更广泛地使用氨甲环酸将提高手术安全性，避免不必要的血液使用，降低输血传播感染的风险，并节省医疗保健资金。“考虑使用氨甲环酸”应纳入安全手术清单。我们有证据，我们需要付诸行动。
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