Department of Anesthesiology and Reanimation, 472602Istanbul Medipol University School of Medicine, Istanbul, Turkey.
Department of Infectious Diseases and Clinical Microbiology, 472602Istanbul Medipol University School of Medicine, Istanbul, Turkey.
Sci Prog. 2022 Jul-Sep;105(3):368504221124055. doi: 10.1177/00368504221124055.
Candidemia is the most common invasive fungal disease in intensive care units (ICUs).
We aimed to investigate cases of candidemia infection developing in the ICU and factors associated with mortality due to this infection.
This is a retrospective study including patients admitted to a tertiary university hospital ICU between January 2012 and December 2020. Patients over 18 years of age who had candida growth in at least one blood culture taken from central or peripheral samples (>48 h after admission to the ICU) without concurrent growth were evaluated.
The study group consisted of 136 patients with candida. Eighty-seven (63.97%) patients were male, with a median age of 69.5 (59-76.5) years. The 7-day mortality rate was 35.29%, while the 30-day mortality rate was 69.11%. As a result of multiple logistic regression analysis, after adjusting for age and malignancy, high APACHE II score and low platelet-lymphocyte ratio (PLR) - were found to be significant factors in predicting both 7-day and 30-day mortality.
In this study, PLR and APACHE II scores were shown to be independent predictors of mortality in patients with candidemia in the ICU.
念珠菌血症是重症监护病房（ICU）中最常见的侵袭性真菌感染。
我们旨在调查 ICU 中念珠菌血症感染病例及与该感染相关的死亡率的相关因素。
这是一项回顾性研究，纳入了 2012 年 1 月至 2020 年 12 月期间在一家三级大学医院 ICU 住院的患者。评估了至少一次从中心或外周样本（入住 ICU 后>48 小时）中采集的血液培养物中生长出念珠菌且无伴随生长的患者。
研究组包括 136 例念珠菌血症患者。87 例（63.97%）患者为男性，中位年龄为 69.5（59-76.5）岁。7 天死亡率为 35.29%，30 天死亡率为 69.11%。经多因素逻辑回归分析，在校正年龄和恶性肿瘤后，高急性生理与慢性健康状况评分系统（APACHE II）评分和低血小板-淋巴细胞比值（PLR）被发现是预测 7 天和 30 天死亡率的显著因素。
在这项研究中，PLR 和 APACHE II 评分被证明是 ICU 中念珠菌血症患者死亡率的独立预测因素。
