Zhang Suifeng, Chen Qian, Wu Lirong, Sun Ke, Lan Xiaofang, Xie Xin, Yan Junfeng
Department of Spleen and Stomach Diseases, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.
Department of Encephalopathy, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.
Evid Based Complement Alternat Med. 2022 Aug 29;2022:5750647. doi: 10.1155/2022/5750647. eCollection 2022.
Depression, a sort of common psychological disorder, is a serious hazard to people's health and social progress. Conventional clinical means for this disorder nowadays are mostly chemical medicine treatments accompanied by psychological counseling. Chinese application of using TCM to treat mental diseases like depression could be traced from hundreds of years ago, in comparison to the long-term depression course and the chemical medicine administration demerits like side effects and resistance, traditional Chinese medicines are milder, more lasting, stable and are the optimal choice for perennial depression treatment. This study was committed to making a comprehensive investigation of Changyu Daotan Decoction's efficacy in the depression mice model, and it turned out that the Changyu Daotan Decoction was capable of restoring the hippocampus of the depression mice and altering the expressions of neurotrophic factors (the expressions of -Catenin, cyclin D1 and in GSK-3 BDNF, GFAP, NGF, and Wnt signaling pathways). Results of metabonomics analysis showed that the contents of GABA, His, Tyr, Trp, PA, and 5-HIAA in the mice of the Changyu Daotan Decoction group were restored after administration and showed a conspicuous relevance with the metabolic.
抑郁症是一种常见的心理障碍，对人们的健康和社会进步构成严重危害。目前针对这种疾病的传统临床手段大多是化学药物治疗并辅以心理咨询。中医治疗抑郁症等精神疾病的应用可以追溯到数百年前，与抑郁症病程长以及化学药物治疗存在副作用和耐药性等缺点相比，中药更为温和、持久、稳定，是长期治疗抑郁症的最佳选择。本研究致力于全面考察畅郁导痰汤对抑郁小鼠模型的疗效，结果表明畅郁导痰汤能够恢复抑郁小鼠的海马体，并改变神经营养因子的表达（β-连环蛋白、细胞周期蛋白D1以及糖原合成酶激酶-3β、脑源性神经营养因子、胶质纤维酸性蛋白、神经生长因子和Wnt信号通路中的表达）。代谢组学分析结果显示，畅郁导痰汤组小鼠给药后γ-氨基丁酸、组氨酸、酪氨酸、色氨酸、苯丙氨酸和5-羟吲哚乙酸的含量恢复正常，且与代谢表现出明显相关性。
