SmI 介导的哌啶和吡咯烷-α-自由基与芳基乙炔砜的分子间加成消除反应。
SmI-mediated intermolecular addition-elimination of piperidine and pyrrolidine -α-radicals with arylacetylene sulfones.
机构信息
Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
出版信息
Chem Commun (Camb). 2022 Sep 27;58(77):10841-10844. doi: 10.1039/d2cc03984b.
PMID:36073180
Abstract
An efficient approach to access α-arylacetylene-substituted pyrrolidine and piperidine derivatives has been developed through a samarium diiodide-mediated addition-elimination process of pyrrolidine and piperidine -α-radicals with arylacetylene sulfones.
摘要
一种通过钐二碘化物介导的吡咯烷和哌啶-α-自由基与芳基乙炔亚砜的加成-消除过程来获得α-芳基乙炔取代的吡咯烷和哌啶衍生物的有效方法已经被开发出来。
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